湿疹3号治疗血虚风燥型慢性湿疹临床研究

Clinical Study of Shizhen 3 for Chronic Eczema of Blood Deficiency and Wind Dryness Type

目的:观察湿疹3号治疗血虚风燥型慢性湿疹的临床疗效。方法:将60例血虚风燥型慢性湿疹患者随机分为治疗组和对照组各30例。治疗组口服湿疹3号,对照组口服盐酸西替利嗪分散片,疗程均为3周。采用湿疹面积及严重程度指数评分法(EASI)及瘙痒程度评分评估患者治疗前后的湿疹面积、严重程度及瘙痒程度,比较2组临床疗效。结果:治疗前,2组EASI评分及瘙痒程度评分比较,差异均无统计学意义(P>0.05)。治疗后,2组EASI评分及瘙痒程度评分均较治疗前降低(P<0.05),治疗组的2项评分均低于对照组(P<0.05)。治疗组的临床疗效优于对照组,差异有统计学意义(Z=-2.514,P=0.012)。治疗过程中,治疗组出现胃肠不适1例,对照组出现嗜睡12例。结论:湿疹3号治疗血虚风燥型慢性湿疹,效果优于盐酸西替利嗪分散片。

Objective. To observe the clinical effect of Shizhen 3 for chronic eczema of blood deficiency and wind dryness type. Methods. Divided 60 cases of patients with chronic eczema of blood deficiency and wind dryness type into the treatment group and the control group randomly, 30 cases in each group. The treatment group received Shizhen 3 orally, while the control group received cetirizine hydrochloride dispersible tablets orally. Both groups received treatment for three weeks. Eczema area and severity index（EASI） and pruritus score were used to evaluate eczema area, severity and pruritus of patients before and after treatment, and the clinical effect was compared between the two groups. Results. No significant difference was found in the comparison of EASI scores and pruritus scores between the two groups before treatment （P 〉 0.05）. After treatment, EASI scores and pruritus scores in both groups were decreased when compared with those before treatment （P 〈0.05）. The two scores in the treatment group were lower than those in the control group （P 〈0.05）. After treatment, the clinical effect in the treatment group was superior to that in the control group, the difference being significant （Z=-2.514, P=0.012）. During treatment, there was one case of gastrointestinal discomfort in the treatment group and 12 cases of sleepiness in the control group. Conclusion= The effect of Shizhen 3 for chronic eczema of blood deficiency and wind dryness type is superior to that of cetirizine hydrochloride dispersible tablets.