MMP-9和VEGF阳性表达与中晚期宫颈癌同步放化疗敏感性的关系

Relationship between the positive expression of MMP-9 and VEGF and the concurrent chemoradiotherapy sensitivity in locally advanced cervical cancer

目的探讨基质金属蛋白酶9(MMP-9)和血管内皮生长因子(VEGF)与中晚期宫颈癌患者同步放化疗敏感性的关系。方法选择60例中晚期宫颈癌患者,均行常规同步放化疗,应用酶联免疫吸附法(ELISA)检测患者术后宫颈癌组织中MMP-9和VEGF的表达水平,分析两者的表达与放化疗疗效的关系。结果 60例患者中,41例患者MMP-9表达阳性,放化疗有效率为61.0%(25/41);19例患者MMP-9表达阴性,放化疗有效率为94.7%(18/19),差异有统计学意义(P﹤0.05)。46例患者VEGF表达阳性,放化疗有效率为63.0%(29/46);14例患者VEGF表达阴性,放化疗有效率为100.0%(14/14),差异有统计学意义(P﹤0.05)。MMP-9和VEGF共同阳性表达患者35例,放化疗有效率为54.3%(19/35);共同阴性表达患者8例,放化疗有效率为100.0%(8/8),MMP-9和VEGF共同阴性表达患者的放化疗有效率高于共同阳性表达患者(P﹤0.05)。结论 MMP-9和VEGF阳性表达与中晚期宫颈癌同步放化疗的敏感性关系密切,MMP-9和VEGF共同阳性表达患者的放化疗疗效差。

Objective To investigate the relationship between the expression of MMP-9, VEGF and the concurrent chemoradiotherapy sensitivity in locally advanced cervical cancer. Method 60 cases of locally advanced cervical cancer patients were treated with conventional concurrent chemoradiotherapy. Enzyme-linked immunosorbent assay（ELISA）was used to detect the expression of MMP-9 and VEGF in cervical cancer tissues after surgery. The relationship between the expression of MMP-9, VEGF and chemoradiotherapy was analyzed. Result Of the 60 patients, 41 were with positive expression of MMP-9, in which the response rate（RR） was 61.0%（25/41）; another 19 patients had negative MMP-9,with RR of 94.7%（18/19）, the difference was statistically significant（P〈0.05）. 46 cases were observed with positive expression of VEGF, and RR was 63.0%（29/46）; 14 had negative VEGF, and 100.0% of RR（14/14）, there was significant difference observed（P〈0.05）. 35 cases had positive expression of both MMP-9 and VEGF, and RR was 54.3%（19/35）;and there were 8 cases of negative MMP-9 and VEGF at the same time, in which the RR was 100.0%（8/8）, and was significantly higher than those with positive MMP-9 and VEGF（P〈0.05）. Conclusion The positive expression of MMP-9and VEGF in locally advanced cervical cancer were closely related to the chemoradiotherapy sensitivity, patients with the positive expression of both MMP-9 and VEGF may have poor response to chemoradiotherapy.