加锡果宁的中枢抑制作用

Depressive effects of edulinine on central nervous system

加锡果宁(Ed)在1/20～1/8 LD_(50)剂量下对小鼠可明显缩短巴比妥或安定的翻正反射消失潜伏期和延长睡眠时间,增强乙醚的麻醉作用,减少自发活动。对某些镇痛药也有增强作用,使家兔脑电呈高幅慢波。延长大鼠总睡眠和慢波睡眠时间,与ip 30mg/kg戊巴比妥钠的作用强度相似,但Ed抑制异相睡眠时间比戊巴妥钠更强。

Edulinine shortened the latency of the righting reflexloss of barbital and diazepam, and prolonged the sleeping time. Edulinine enhanced the narcotic action of ether, and decreased the spontaneous activity, also partial reversion produced by caffeine in mice. The potentiation of edulinine on the analgesic action of morphine in mice was observed.A gradual EEG change from the low voltage rapid wave to the high voltage slow one was observed in rabbits after iv 10 mg / kg edulinine.The hypnotic effect of edulinine was investigatedin rats. Edulinine as well as sodium pentobarbital prolonged the slow wave sleeping time and total sleeping time significantly, whereas the rapid eye movement sleeping time was reduced. It has been shown that a dose of 120 mg/ kg edulinine was more effective than that of 30 mg / kg sodium pentobarbital, so far as their effects on REMT was concerned.