MTHFR基因A1298C位点的多态性与亚洲人群乳腺癌发生关系的meta分析

Association between MTHFR A1298C polymorphism and breast cancer in Asain population: a meta-analysis

目的采用meta分析的方法定量评价亚甲基四氢叶酸还原酶(MTHFR)基因A1298C位点的多态性与亚洲人群乳腺癌发生的相关性。方法计算机检索PubMed、EMBASE、Web of science、中国生物医学文献数据库、中文科技期刊数据库、中国期刊全文数据库和万方数据库,搜索有关MTHFR基因A1298C位点的多态性与亚洲人群乳腺癌发生关系的病例对照研究,检索时间为建库至2017年3月。采用Stata 12.0软件进行meta分析。结果共纳入19篇文献进行meta分析,共计7 454例乳腺癌患者(病例组)和8 255位健康对照者(对照组)。meta分析结果显示:2组患者的AA基因型和AC基因型频率[OR=0.97,95%CI为(0.91,1.04),P=0.374]、AC基因型及CC基因型频;率[OR=0.87,95%CI为(0.75.1.01).P=0.060]、AA基因型和CC基因型频率[OR=0.87,95%CI为(0.76.1.01).P=0.061]、AA+AC基因型和CC基因型频率[OR=0.88,95%CI为(0.76,1.01),P=0.061]及AC+CC基因型和AA基因型频率[OR=0.99,95%CI为(0.93,1.06),P=0.737]比较差异均无统汁计学意义.结论 MTHFR基因A1298C位点的多态性与亚洲人群乳腺癌的发生无关。

Objective To evaluate the association between methylene tetrahydrofolate reductase （MTHFR） A1298C polymorphism and breast cancer in the Asain population. Methods PubMed, EMBASE, Web of science, Chinese Biomedical Literature Database, Chinese Science and Technology Academic Periodical Database, Chinese Journal Full-Text Database, and Wanfang Database were searched to identify relevant articles that investigated the association of MTHFR A1298C polymorphism with breast cancer, the articles published time was from inception of database to March 2017. A meta-analysis was performed by using the Stata 12.0 software. Results A meta-analysis of 19 case-control studies was performed including 7 454 cases of breast cancer and 8 255 controls. The results of meta-analysis suggested that there was no significant association between MTHFR A1298C polymorphism and breast cancer for the Asain population under five genetic models [ AA vs AC： 0R=0.97, 95% CI was （0.91, 1.04）, P=0.374; AC vs CC： OR=0.87, 95% CI was （0.75, 1.01）, P=0.060; AA vs CC： OR=0.87, 95% CI was （0.76, 1.01）, P=0.061; AA＋AC vs CC： OR=0.88, 95% CI was （0.76, 1.01）, P=0.061; AC＋CC vs AA： OR=0.99, 95% CI was （0.93, 1.06）, P=0.737 ]. Conclusion MTHFR A1298C polymorphism is not associated with breast cancer in the Asain population.