健康孕妇和子痫前期孕妇黄斑中心凹视网膜厚度和黄斑中心凹下脉络膜厚度对比观察

Comparison of central foveal thickness and subfoveal choroidal thickness in healthy pregnancy and pre-eclampsia

目的对比观察健康孕妇和子痫前期孕妇的黄斑中心凹视网膜厚度（CFT）和黄斑中心凹下脉络膜厚度（SFCT）。方法前瞻性对照研究。在妇产科确诊为子痫前期的孕妇20例20只眼（子痫前期孕妇组）以及健康孕妇20名20只眼（健康孕妇组）、正常女性20名20只眼（正常女性组）纳入研究。子痫前期孕妇组与健康孕妇组受检者的孕周比较，差异无统计学意义（χ2=0.012，P=0.913）；3组受检者之间年龄、等效球镜度数比较，差异无统计学意义（χ2=1.760、0.087，P=0.413、0.957）。所有受检眼均行光相干断层扫描检查，应用仪器自带的测距软件测量视网膜神经上皮层内界膜至视网膜色素上皮层强反光带内侧的距离，并以此作为CFT；测量Bruch膜强反射线到脉络膜巩膜交界面强反射线的垂直距离，并以此作为SFCT。对比分析3组受检眼CFT及SFCT的差异。结果正常女性组、健康孕妇组、子痫前期孕妇组受检眼CFT分别为（194.40±16.17）、（201.20±17.33）、（199.00±15.46）μm；SFCT分别为（263.45±69.66）、（330.00±49.20）、（373.40±52.00）μm。3组受检眼CFT比较，差异无统计学意义（χ2=0.888，P=0.641）；SFCT比较，差异有统计学意义（χ2=22.818，P=0.000）。健康孕妇组受检眼SFCT较正常女性组增加，差异有统计学意义（Z=？2.991，P=0.002）。子痫前期孕妇组受检眼SFCT较健康孕妇组增加，差异有统计学意义（Z=？2.638，P=0.007）。结论子痫前期孕妇较健康孕妇SFCT增加，CFT无明显差异。

ObjectiveTo compare the central foveal thickness （CFT） and subfoveal choroidal thickness （SFCT） in healthy pregnant women and patients with pre-eclampsia.MethodsA prospective control study. Twenty normal subjects, 20 healthy pregnant women and 20 patients with pre-eclampsia were included. The difference of gestational weeks between healthy pregnant women and patients with pre-eclampsia was not significant （χ2=0.012, P=0.913）. The differences of age and spherical equivalent among normal subjects, healthy pregnant women and patients with pre-eclampsia were not significant （χ2=1.760, 0.087; P=0.413, 0.957）. All eyes underwent optical coherence tomography examination to measure the CFT and SFCT.ResultsThe mean CFT of normal subjects, healthy pregnant women and patients with pre-eclampsia were （194.40±16.17）, （201.2±17.33）, （199.00±15.46） μm, there was no significant difference among the three groups （χ2=0.888, P=0.641）. The mean SFCT of normal subjects, healthy pregnant women and patients with pre-eclampsia were （263.45±69.66）, （330.00±49.20）, （373.40±52.00） μm, there was significant difference among the three groups （χ2=22.818, P=0.000）. The mean SFCT of healthy pregnant women was increased than that of normal subjects （Z=？2.991, P=0.002）. The mean SFCT of patients with pre-eclampsia was increased than that of healthy pregnant women （Z=？2.638, P=0.007）.ConclusionThe mean SFCT of patients with pre-eclampsia is increased than healthy pregnant women.