内镜黏膜下剥离术治疗食管原位癌的临床研究

Endoscopic submucosal dissection for the treatment of esophageal carcinoma in situ

目的:探讨内镜黏膜下剥离术治疗食管原位癌的安全性及有效性。方法:2012年8月至2016年3月,应用内镜黏膜下剥离术治疗8例食管原位癌。观察手术时间、术后并发症、住院时间、住院费用及术后随访。结果:手术时间55~165分钟,均为术中少量出血,无穿孔,1例环周病变为预防食管狭窄置入食道支架,无中转开胸及死亡病例,住院时间6~10天,住院费用10 626.11元~27 094.97元。8例随访6~44个月,未见复发,1例食管支架拔除后食管狭窄,再次置入食管支架拔除后进食顺利。结论:内镜黏膜下剥离术治疗食管原位癌是安全有效的。

Objective：To investigate the safety and efficacy of endoscopic submucosal dissection in the treatment of esophageal carcinoma in situ. Methods： A total of 8 patients with esophageal carcinoma in situ underwent endoscop- ic submucosal dissection from August 2012 to March 2016 were collected. The operation time, postoperative eomplica- tions, hospitalization time, hospitalization expenses and postoperative follow - up were observed. Results： The operation time was 55 minutes to 165 minutes. All were intraoperative bleeding. There was no perforation. In order to prevent e- sophageal stenosis, esophageal stent was inserted in 1 case of circumferential lesions in esophagus. No transfer open chest and deaths. The hospitalization time was 6 days to 10 days. The hospitalization cost was RMB 10 626.11 to RMB 27 094.97. Eight cases were followed up for 6 to 44 months, no recurrence. 1 case occured esophageal stricture after esophageal stent removal, eating well after inserting esophageal stentt again. Conclusion：Endoscopic submucosal dis- section for the treatment of esophageal carcinoma in situ is safe and effective.