WNT5B在卵巢上皮癌中的表达及意义

Expression and significance of WNT5B in epithelial ovarian cancer

目的:探究WNT5B在卵巢上皮癌中的表达情况,结合临床病理参数,分析其临床意义。方法:运用免疫组化SP法检测80例卵巢上皮癌和19例正常卵巢组织中WNT5B蛋白的表达,并分析其表达与卵巢癌的分化程度、临床分期、病理类型、大网膜与淋巴结转移的关系。结果:WNT5B蛋白在卵巢上皮癌中的阳性表达率及表达强度低于正常卵巢(P<0.05)。随分化程度升高,WNT5B蛋白在卵巢上皮癌中的阳性表达率及表达强度逐渐升高(P<0.05)。WNT5B在卵巢上皮癌原发灶中的阳性表达率及表达强度均显著低于大网膜转移灶及淋巴结转移灶中的阳性表达率及表达强度(P<0.05)。卵巢上皮癌临床分期越高,WNT5B在卵巢上皮癌中的阳性表达率及表达强度越低(P<0.05)。WNT5B在卵巢上皮癌中的阳性表达率及表达强度与病理类型无关(P>0.05)。结论:WNT5B蛋白在卵巢上皮癌组织中的表达明显低于正常卵巢组织,可能参与了卵巢上皮癌发生的过程。WNT5B蛋白在卵巢上皮癌中的表达与分化程度、转移情况及临床分期有关。

Objective：To investigate the expression of WNT5B in ovarian epithelial carcinoma and analyze its clin- ical significance. Methods：The expression of WNT5B protein was tested by SP immunohistochemical method in 80 cases of ovarian epithelial tumor and 19 cases of normal ovarian tissues. Then analyze the relationship between the ex- pression of ovarian cancer and clinicopathological features, such as clinical stage, pathological type, metastasis of lymph node and omentum. Results：The positive expression rate of WNTSB protein in ovarian epithelial carcinoma was lower than that in normal ovarian tissues（ P 〈 0.05 ）. The positive expression rate and expression intensity of WNTSB protein increased with the increase of differentiation（ P 〈 0. 05 ）. The positive expression rate and expression intensity of WNTSB in primary epithelial ovarian cancer were significantly lower than that in the metastatic lesions and lymph node metastasis （P 〈 0.05 ）. In addition, the higher the elinieal stage of ovarian epithelial carcinoma was, the lower the positive expression rate and expression intensity of WNTSB was （P 〈 0.05）. The positive expression rate and the expression intensity of the median of WNTSB in epithelial ovarian cancer were not related with pathological type （P 〉 0.05 ）. Conclusion： The expression of WNTSB protein in ovarian epithelial carcinoma was significantly lower than that in normal ovarian tissue. WNT5B is involved in the process of ovarian epithelial carcinoma. The expression of WNT5B protein in ovarian epithelial carcinoma is related to the degree of differentiation,metastasis and clinical stage.