去甲基构树宁B的合成

Synthesis of Demethylbroussonin B

以1,3-二羟基苯和对羟基苯甲醛为起始原料,经赫氏酰化、羟基保护、克莱森-斯密特缩合及催化氢化反应首次合成天然产物去甲基构树宁B,总收率40.9%,其结构经~1H NMR,^(13)C NMR和HR-MS(ESI-TOF)确证。

The synthesis of natural product demethylbroussonin B with the over yield of 40.9% was firstly achieved through Houben-Hoesch reaction, hydroxyl protection, claisen-schmidt condensation reaction and catalytic hydrogenation, using 2,4-dihydroxy acetophenone and p-hydroxyhenzaldehyde as the starting materials. The structure was confirmed by I H NMR, 13C NMR and HR-MS（ESI-TOF）.