儿童哮喘急性发作采用高剂量糖皮质激素雾化吸入法的临床研究

Clinical study of acute exacerbation of childhood asthma with high dose glucocorticoid inhalation

目的:研究使用高剂量糖皮质激素雾化吸入法治疗儿童哮喘急性发作的临床疗效。方法:选取来我院确诊为儿童哮喘急性症状95例,其中随机将患者分为两组,观察组50例,观察组在吸入β—受体激动剂的基础上吸入高剂量的糖皮质激素;对照组吸入β—受体激动剂及常规剂量糖皮质激素观察治疗后,两组患者在呼吸频率、心率、血氧饱和度、FEV1、PEF等指标的比较。结果:当在治疗1小时后,发现观察组的呼吸频率27.6±2.9(次/min),心率值82.9±1.9(次/min),显著小于对照组(36.7±3.1次/min、95.9±2.4(次/min))(P<0.05)。观察组的血氧饱和度和PEF相比对照组升高,两者具有显著性差异(P<0.05)。结论:高剂量糖皮质激素在治疗儿童哮喘急性发作方面具有较好的疗效。

[object]：To study the clinical efficacy of edible high- dose glucocorticoid inhalation therapy for acute exacerbation of childhood asthma. Methods： Fifty--nine patients with acute asthma were randomly divided into two groups： observation group （n = 50）, Inhalation of β-agonists and glucocorticoid tablets were observed in the control group by inhalation of high doses of glucocorti- coids on the basis of inhalation of β-agonists. After treatment, the two groups of patients in the respiratory rate, heart rate, oxygen saturation, FEV1, PEF and other indicators of comparison. Results After 1 hour of treatment, the respiratory rate of the observation group was 36.7 ± 3.1 （times / min）, and the heart rate was 5.9 ± 2.4 （times / min） was much lower than that of the control group （27.6± 2.9,82.9 ± 1.9 ）） （P 〈0.05）. The oxygen saturation and PEF of the observation group were higher than those of the control group （P 〈0.05）. Conclusion High - dose glucocorticoid has a good effect in the treatment of acute exacerbation of childhood asthma.