恶性黑色素瘤10例临床病理分析

Malignant melanoma:a clinicopathologic analysis of 10 cases

目的:探讨恶性黑色素瘤(以下简称黑色素瘤)的病理形态学特征,诊断要点及组织发生。方法:采用常规HE染色及免疫组化SP法分析10例黑色素瘤,并复习文献。结果:黑色素瘤的细胞形态和组织结构具有多样性。镜下可见上皮样细胞、梭形细胞、小细胞、气球样细胞以及巨细胞,组织结构上可呈巢状、片状、腺泡状、束状、肉瘤样或弥漫排列。黑色素瘤可无色素或有大量色素沉着。免疫组化示肿瘤细胞HMB45、melan-A和S-100阳性率≥80%。结论:黑色素瘤具有形态多样性和易混淆性,确诊依赖于病理组织学和免疫组织化学。

[ objective] ： To explore the pathological features and diagnositic criteria of malignant melanoma and its histogenesis. Methods Ten mentioned cases were investigated by hematoxylin-eosin and S-P immunohistochemical staining.The clinical and path- ologic features were analyzed with reviewe of the literatures. ResultsThe histopathologic structures and cell morphological variation are very complex.Microscopically, there were epithelioid cells, spindle cells, small cell, balloon-- like cells, and giant cells.It can be ar- ranged as nested type, flake type, alveolar type, bundle type, sarcomatoid or diffusing in view of histologic.Melanoma can be expressed as no or a lot of pigmentation. Immunohistochemical stain showed that the tumor cells were more than or equal to 80% positive for HMB45, melan-A and S-100 protein. Conclusions Morphological diversity and easy to confuse are general features of melanoma. Its definite diagnosis should rely on the histopathological and immunohistochemical features.