新时期细菌性角膜炎的临床处置要点

Clinical management of bacterial keratitis in the new era

细菌性角膜炎是常见的感染性角膜炎，多数患者即使治愈后也会有严重的视力损害。由于病原菌耐药性的逐渐增强，现有抗生素对细菌性角膜炎的治疗效果越来越差。面对这一挑战，本文从诊断和治疗的角度将近年来细菌性角膜炎的临床处置经验进行了概述。除对感染灶标本取材、常见培养基和抗生素选择的共识进行了归纳和总结外，还介绍了一种有效且实用的，治疗严重、顽固性眼表感染的眼睑下抗生素持续灌注给药方法。

Bacterial keratitis is a common infectious keratitis. Patients often end up with severe vision loss even after the infection is completely eradicated. With the increasing resistance of pathogens to antibiotics, treatment of bacterial keratitis has become increasingly difficult. Facing such an emerging challenge, the present review outlined recent clinical experience in the diagnosis and treatment of bacterial keratitis. In addition to a summary on practice standards in specimen collection, selection of common culture media and antibiotics, a new simple and efficacious antibiotic delivery method is introduced using continuous subpalpebral lavage for the treatment of severe and recalcitrant bacterial keratitis.