长链非编码RNAs与细胞分化

Review on Correlation Between Long Non-coding RNAs and Cell Differentiation

随着遗传学及生物信息学技术的快速发展,曾被称为转录"噪音"的长链非编码RNAs(Long non-coding RNAs,LncRNAs)越来越受到学者们的广泛关注。研究发现,LncRNAs在生物体各种生命活动中具有重要的调节作用,其对基因表达的调控作用已成为生命科学研究的热点问题。研究证实,LncRNAs通过信号分子、诱饵分子、引导分子、支架分子等方式,对遗传、转录及转录后等进行水平调控,如细胞分化等生物学过程。本文就LncRNAs与细胞分化的关系作一综述,包括LncRNAs与多能干细胞多能性的维持及分化、与神经细胞分化、与肌肉分化、与成骨细胞分化的机制,以及LncRNAs与口腔鳞状细胞癌的关系。

With the rapid development of genetics and bioinformatics technology, the long non--coding RNA （LncRNA） which once was considered as the transcription ＂noise＂, is now attracted more and more attention. It has been confirmed that LneRNA plays an important regulation role in almost all kinds of life activities, especially in the process of regulating gene expression by signaling molecules, decoy molecules, lead molecules, and scaffold mo- lecular, etc, which has been one of the most hottest issues in life science. It is also known that LncRNAs performs their biological functions at different levels, including cell differentiation. This paper is to discuss the correlation be- tween LneRNAs and cell differentiation, which includes LncRNAs with pluripotent stem cells who maintain their pluripotency and differentiation, LncRNAs with nerve cell differentiation, LneRNAs with muscles differentiation, and LncRNAs with osteoblast differentiation.