不同剂量盐酸氨溴索注射液治疗老年脑卒中相关性肺炎的效果比较

Comparison of different doses of Ambroxol Hydrochloride Injection in the treatment of stroke-related pneumonia in the elderly

目的观察不同剂量盐酸氨溴索注射液治疗老年脑卒中相关性肺炎(Stroke-related pneumonia,SPA)的临床疗效。方法选取2016年1月~2017年6月我院收治的90例确诊为SAP患者为研究对象,随机分为低剂量盐酸氨溴索组(低剂量组30例)、高剂量盐酸氨溴索组(高剂量组30例)和对照组(30例),对照组仅给予常规抗生素治疗,盐酸氨溴索组辅以不同剂量的盐酸氨溴索治疗,比较三组患者的抗生素使用时间、退热时间、住院时间、动脉血氧分压、C反应蛋白及细菌清除率,分析三组临床疗效。结果高剂量组和低剂量组的临床治疗总有效率均高于对照组(P<0.05),且高剂量组高于低剂量组,差异有统计学意义(P<0.05);高剂量组和低剂量组的抗生素使用时间、退热时间、住院时间明显短于对照组(P<0.05),且高剂量组短于低剂量组,差异有统计学意义(P<0.05);高剂量组和低剂量组的动脉血氧分压高于对照组(P<0.05),且高剂量组高于低剂量组,差异有统计学意义(P<0.05);三组治疗后C反应蛋白水平无明显差异,差异无统计学意义(P>0.05);高剂量组细菌清除率为90.27%,低剂量组细菌清除率为68.51%,对照组细菌清除率为57.80%,三组细菌清除率比较差异有统计学意义(P<0.05);三组临床不良反应发生率比较差异无统计学意义(P>0.05)。结论高剂量盐酸氨溴索治疗SPA的疗效显著,可提高细菌清除率,且临床较为安全,值得推广应用。

Objective To investigate the clinical efficacy of different doses of Ambroxol Hydrochloride in the treatment of stroke-related pneumonia in the elderly.Methods A total of 90 patients with acute stroke were diagnosed as SAP in our hospital from January 2016 to June 2017.They were randomly divided into low-dose Ambroxol Hydrochloride group （low-dose group 30 cases）,high-dose Ammonia Bovine group （high-dose group 30 cases） and control group （30 cases）. The control group received only routine antibiotic therapy.Ambroxol Hydrochloride group was supplemented with differ- ent doses of Ambroxol Hydrochloride,and the antibiotic use time,fever time,hospitalization time,arterial oxygen partial pressure,C-reactive protein and bacterial clearance rate,analyed of three groups of clinical efficacy.Results The total effective rate of high-dose group and low-dose group was higher than that of control group （P〈O.O5）,and high-dose group was higher than low-dose group,the difference was statistically significant （P〈0.05）.The antibiotic use time,fever time and hospitalization time of the high dose group and low dose group were significantly shorter than those of the control group（P〈 0.05）,and the high dose group was shorter than that of low dose group,the difference was statistically significant （P〈 0.05）.The high dose group was higher than that of low dose group （P〈0.05）,and the high dose of group and low dose group was higher than that of control group, the difference was statistically significant （P〈0.05）.There was no significant difference in C-reactive protein between the three groups （P〉0.05）.The bacterial clearance ratein the high-dose group was 90.27% and the low-dose group was 68.51%.The bacterial clearance rate in the control group was 57.80%,and the difference was statistically significant （P〈0.05）.There was no significant difference in the incidence of clinical adverse reactions between the three groups （P〉0.05）.Conclusions High-dose Ambroxol Hydrochloride in the treatment of stroke-related pneumonia in elderly patients with significant effect,can improve bacterial clearance,and clinical safer, worthy of promotion and application.