小剂量米非司酮治疗子宫腺肌症的临床效果

Clinical effect of low-dose Mifepristone in the treatment of adenomyosis

目的探讨小剂量米非司酮治疗子宫腺肌症的临床治疗效果。方法选取2015年4月~2016年5月我院收治的87例子宫腺肌症患者作为研究对象,采用奇数偶数法将所有患者分为两组,即对照组43例和观察组44例。对照组患者采用大剂量(剂量为观察组的两倍)米非司酮治疗,观察组给予小剂量米非司酮治疗。观察两组患者的临床治疗效果。结果治疗后,观察组患者的月经量多于对照组,药物不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论对子宫腺肌症患者使用不同剂量的米司非酮治疗,都取得了良好的治疗效果,但小剂量米司非酮的治疗效果更为显著,可有效改善的患者月经量,减少不良反应的发生率,安全性更高,值得临床推广应用。

Objective To investigate the clinical effect of low-dose Mifepristone in the treatment of adenomyosis.Methods From April 2015 to May 2016,87 adenomyosis patients treated in our hospital were selected as research objects.By an odd and even numbers method,all participants were divided into two groups,control group （n=43） and observation group （n=44）.ln the control group,large-dose Mifepristone （double dose compared with the observation group）,while in the observation group,low-dose Mifepristone was adopted.The clinical therapeutic effect in the two groups was observed. Results After treatment,the patients in the observation group had more menstrual flow than the control group.The incidence of adverse drug reactions was significantly lower than that in the control group,and the differences were statistically significant （P〈0.05）.Conclusion For adenomyosis patients,application of Mifepristone in different doses both can obtain favorable effects,but more remarkable in a low dose,which effectively improves the menstrual amount and reduces the occurrence of adverse reactions in higher safety.h is worthy of clinical application and promotion.