摘要
浅蓝霉素类化合物是一类微生物产生的的生物碱,结构中大多含有1个2,2′-联吡啶母核。自从1959年发现首个浅蓝霉素类化合物(浅蓝霉素A)以来,共报道了49个天然来源的浅蓝霉素类化合物。由于2,2′-联吡啶和醛肟基团的存在,浅蓝霉素类化合物表现出抗菌活性、细胞毒活性、免疫调节等生物活性,一直是化学家、生物学家和药物学家重点关注的对象。本文综述了这49个天然来源的浅蓝霉素类化合物的结构与生物活性,旨在为该类化合物的深入研究提供有益的参考。
Caerulomycins(CRMs)are a kind of natural alkaloids featuring a 2,2′-bipyridine nucleus.Since the caerulomycin A was identified from the fermentation products of Streptomyces caeruleus PRL1687 in 1959,there have been reported 49 natural CRMs and their analogues from microorganisms.CRMs and their analogues exhibited potential bioactivities such as antimicrobial,cytotoxic and immunosuppressive activities due to the 2,2′-bipyridine nucleus and aldoxime group,and thus attracted the interest of chemists and biologists.This review summarized the structures and bioactivities of these compounds.
作者
梅显贵
蓝萌萌
金言正
朱伟明
MEI Xian-gui;LAN Meng-meng;JIN Yan-zheng;ZHU Wei-ming(Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003,Chin)
出处
《中国海洋药物》
CAS
CSCD
2017年第5期83-92,共10页
Chinese Journal of Marine Drugs
基金
国家自然科学基金项目(81561148012
41376148)
国家自然科学基金联合资助重点项目(U1501221)
青岛市海洋生物医药科技创新中心建设专项项目(2017-CXZX01-3-7)资助
关键词
微生物
天然产物
浅蓝霉素
生物活性
microorganisms
natural products
caerulomycins
bioactivity