摘要
甲基苯丙胺(methamphetamine,MA)属于苯丙胺类中枢兴奋剂(amphetamine-type stimulants,ATS)。MA和阿片类传统毒品相比,最大的区别在于其强烈的精神成瘾性,且具有复吸率高、易获得、躯体戒断症状不明显等特点,且其成瘾神经机制非常复杂,涉及多个脑区、多种神经递质及多条神经通路,与多种基因以及自噬等密切相关。探索MA成瘾的神经机制,为其预防和治疗提供思路和方法已刻不容缓。本文就MA成瘾机制的最新研究进展做一综述。
Methamphetamine（ MA）,is one of amphetamine-type stimulants（ ATS）. Compared with traditional opioid drugs,the biggest difference of MA is its strong psychological dependence,and with high relapse rate,easy to get,unconspicuous physical withdrawal symptoms. Its addiction mechanism is complex,involving multiple brain regions,a variety of neurotransmitters and neural pathways,and a variety of genes and autophagy are closely related. Therefore,exploring the neural mechanism of MA addiction to provide ideas and methods for its prevention and treatment is imperative. In this paper,a summary of the latest progress of MA addiction mechanism was reviewed.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2017年第21期2541-2545,共5页
Chinese Journal of New Drugs
基金
国家自然基金面上项目(81571354)
