食管癌CD34 VEGF表达与CT强化幅度的关系

The Relationship between the Expression of CD34 and VEGF and the Magnitude of CT Enhancement in Esophageal Carcinoma

目的:分析食管癌CD34、VEGF表达与CT强化幅度的关系。方法:采集我院收治的40例食管癌患者和20例健康人群的食管粘膜组织,应用免疫组化的方法检测粘膜组织中CD34和VEGF的蛋白表达水平,并对MVD值进行计数,测量CT增强扫描癌灶的CT强化值,进一步分析各指标之间的关系及其与肿瘤临床分期的关系。结果:与健康对照组相比,患病组组织CD34和VEGF的表达阳性率均较高(P<0.05),且二者的表达呈正相关(r=0.451,P<0.05);食管癌组织中VEGF的表达和MDV均与食管癌的浸润深度、淋巴结转移情况、细胞分化程度和TNM分期相关(P<0.05);食管癌组织中VEGF(r=0.434,P<0.05)和MVD(r=0.463,P<0.05)均与螺旋CT强化幅度呈正相关,差异均具有统计学意义。结论:食管癌组织中CD34和VEGF均呈高表达,并且与CT强化幅度呈正相关,联合检测CD34和VEGF的表达可以作为食管癌的侵袭转移和预后评估的重要指标。

Objective: To analyze the relationship between the expression of CD34 and VEGF and the enhancement of CT in esophageal carcinoma. Methods: The organization of esophageal mucosa in 40 cases of esophageal carcinoma and 20 cases of healthy people were collected from our hospital,the expression of CD34 and VEGF protein were detected by immunohistochemistry in tissue,and the MVD was counted,measured CT scan cancer CT enhancement value,will be between the indexes and clinical stages of the tumor and its relation to statistics analysis. Result: Compared with healthy control group,the positive expression rate of CD34 and VEGF in esophageal carcinoma group were higher( P < 0. 05),and they were positively correlated in esophageal cancer tissues( r = 0.451,P < 0.05); The expression of VEGF and MDV in esophageal carcinoma were correlated with the degree of cell differentiation,depth of invasion,lymph node metastasis and clinical TNM stage( P <0.05); the expression of VEGF in esophageal cancer tissues( r = 0.434,P <0.05) and MVD( r= 0.463,P<0.05) with spiral CT enhancement was positively correlated,the differences were statistically significant. Conclusion: CD34 and VEGF were highly expressed in esophageal cancer,and CD34,VEGF and CT enhancement in esophageal carcinoma are related,are important indicators of combined detection can be used as the invasion and metastasis of esophageal carcinoma and prognosis judgement.