摘要
动脉粥样硬化是由内皮细胞、巨噬细胞、平滑肌细胞等多种细胞功能障碍所致的血管壁疾病,异常血脂为其重要导火索。近年来大量研究表明Wnt蛋白在不同种类细胞中广泛表达,并且对内皮损伤,巨噬细胞泡沫化等方面具有显著的调节作用。现具体综述Wnt/β-catenin信号通路在动脉粥样硬化发生及发展中的作用。
Atherosclerosis is a vascular wall disease,which is caused by the various cell dysfunction such as endothelial cells,macro- phages, smooth muscle cells and other cells. Dyslipidemia is a pivotal cause for this disease. In recent years, numerous studies have shown that Wnt signaling is widely expressed in different types of cells and also has dramatically regulations on endothelial injuries,macrophage acti-vation and other aspects. This review will elaborate the role of Wnt/beta-catenin signaling pathway in the occuirence and development of ath-erosclerosis.
出处
《心血管病学进展》
CAS
2017年第6期676-679,共4页
Advances in Cardiovascular Diseases
基金
哈尔滨医科大学心肌缺血教育部重点实验室开放课题(KF201612)
