摘要
动脉粥样硬化是一种炎性疾病,多由血脂异常引起,是心血管疾病的主要病理基础。1992年,载脂蛋白E基因敲除小鼠的问世,由于其在正常饮食下能够形成更接近于人类动脉粥样硬化模型的病理特点,成为研究动脉粥样硬化的理想模型。两者的结合,便于人们进一步了解动脉粥样硬化的病理机制,也为研究中药、西药药效及其作用机制提供了保障,现就载脂蛋白E基因敲除小鼠在动脉粥样硬化研究中的应用做一综述。
Atherosclerosis is an inflammatory disease and the main pathological basis of cardiovascular disease,which is caused by dyslipidemia. In 1992,ApoE-knockout mice became the ideal model for the study of atherosclerosis due to their ability to form a pathological model closer to the human atherosclerotic model under normal diet. The combination of the two,facilitate further understanding of the patho-logical mechanisms of atherosclerosis, and provide a guarantee for the study of the efficacy of Chinese medicine and Western medicine and its mechanism. This paper is a review of ApoE-knockout mice for atherosclerosis research.
出处
《心血管病学进展》
CAS
2017年第6期679-683,共5页
Advances in Cardiovascular Diseases
基金
国家自然科学基金青年基金课题(81403365)
