少数民族地区健康人群血管内皮功能的影响因素及超声诊断价值

The influence factors of endothelial function and the diagnosis value of ultrasonography among healthy people in ethnic minority region

目的 :探讨广西少数民族地区健康人群血管内皮功能的影响因素及超声诊断价值。方法 :选取广西少数民族地区749例20~80岁健康人群作为研究对象,内容涉及问卷、一般体格检查及超声检测肱动脉血流介导内皮依赖性舒张功能(FMD)、反应性充血前后的肱动脉血管内径、血流速度及出现变化的时间。结果:不同民族、年龄、性别、吸烟组的FMD差异有统计学意义;Logistic回归分析结果显示,民族、年龄、性别是FMD的独立影响因素;相关性分析显示,FMD与肱动脉血管内径、管腔内血流速度呈显著负相关,与扩张达峰时间及最大血流速度出现时间呈显著正相关。结论:FMD存在民族差异性,年龄、性别与血管内皮功能损害的发生有关,超声检测指标可评估血管内皮功能的变化。

Objective：To explore the influence factors of endothelial function and the diagnosis value of ultrasonography among healthy people in ethnic minority region in Guangxi Province. Methods：749 healthy people aged 20~80 years old were selected as the research objects. Research content contained questionnaire,physical examination and the brachial flow-mediated dilation（FMD） measured by ultrasound,brachial artery diameter,blood flow velocity and the time of change before and after the reactive hyperemia. Results：Nationality,age,gender,smoking set had statistical significances in FMD. Logistic regression analysis results showed that the nationality,age and gender were independent factors affecting vascular endothelial function;correlation analysis showed that FMD had significantly negative correlation with brachial artery diameter,the blood flow velocity,and significantly positively correlated with the expansion of the peak time and the blood flow velocity maximum time. Conclusions：Endothelial function exists ethnic differences,and age and gender participates in the pathogenesis of endothelial function damage.Ultrasonic testing index can be used to response the changes of vascular endothelial function.