香菇多糖联合XELOX方案治疗老年晚期结直肠癌临床观察

Clinical observation of lentinan combined with XELOX regimen in elderly patients with advanced colorectal cancer

目的探讨香菇多糖联合XELOX方案治疗老年晚期结直肠癌近期疗效、毒副反应以及生活质量改善等情况。方法 108例老年晚期结直肠癌患者随机分为香菇多糖组(香菇多糖联合XELOX方案)和对照组(XELOX方案)。结果香菇多糖组和对照组有效率分别为31.4%和25.9%,疾病控制率分别为68.5%和53.7%,两组比较无统计学意义(P>0.05);香菇多糖组可有效减少化疗所致的胃肠道反应包括恶心呕吐、腹泻的发生率,同时明显降低手足综合征的发生率,香菇多糖组及化疗组分别为38%和72%,两组差异存在统计学意义(P<0.05);生活质量评分提高率分别为59.2%与37.0%,差异有统计学意义(P<0.05)。结论老年晚期结直肠癌应用香菇多糖可改善一般状态,提高生活质量,减少化疗中的部分毒副反应,提高患者耐受性。

Objective： To investigate XELOX lentinan joint program in the short-term efficacy,toxicity and quality of life improvement and so on. Methods： 108 cases of elderly patients with advanced colorectal cancer were randomly divided into two groups： lentinan（ lentinan combined XELOX program） and control group（ XELOX scheme）. Results： The efficacy rate was 31. 4% and 25. 9% respectively in the lentinan group and the control group,disease control rate was 68. 5% and 53. 7%respectively,and the two groups were not statistically significant（ P〈0. 05）; the lentinan group effectively reduced chemotherapy induced gastrointestinal reactions including nausea,vomiting,diarrhea incidence,while significantly reducing the incidence of hand-foot syndrome,which were 38% and 72% in the lentinan group and chemotherapy group,and the difference was statistically significant（ P〈0. 05）; life quality score increase rates were 59. 2% and 37% respectively,and the difference was statistically significant（ P〈0. 05）. Conclusion： The application of lentinan in the elderly with in advanced colorectal cancer can improve the general condition and quality of life,reduce chemotherapy toxicity in part,and improve patient tolerance.