EV71致重症手足口病死亡的法医病理学研究

The forensic pathological research to the children that died with severe hand-foot-and-mouth disease caused by EV71

目的通过观察由新肠道病毒(EV71)引起的重症手足口病(hand-foot-and-mouth,HFMD)死亡病例多器官组织病理学改变,探讨其损伤机制。方法收集由EV71致重症HFMD死亡病例8例,进行尸体解剖并提取心、脑、肺等多个器官,各器官经制片后进行组织病理学检查。结果患儿各器官淤血、肿大并见重度病毒性炎性病变,以大脑、肺、免疫器官损伤最为明显。结论 EV71致重症HFMD死亡患儿全身多脏器发生炎性病变,以脑、肺及免疫器官损伤为重,可能是导致患者死亡的主要原因。

Objective To observe the pathological changes of some organs of the children who died with severe hand-foot-and-mouth disease [HFMD] caused by New enterovirus(EV71).Methods The corps of the children who died with the severe HFMD were selected.And then autopsy was carried out.The organs were taken out for fixing,and drawing materials and slice.In the end,the histopathological? examination were made.Results All the organs were congestion,swelling and see the inflammatory lesions caused by viral with microscope.The brain,lung and immune organs were the most serious.Conclusion The HFMD caused by EV71 can cause inflammatory lesions,especially in the brain,lung and immune organs.It may be the main causes of death.