纤维支气管镜肺泡灌洗对慢性阻塞性肺疾病急性加重期患者肺功能的影响

Effect of bronchoalveolar lavage on pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease

目的探讨纤维支气管镜肺泡灌洗对慢性阻塞性肺疾病急性加重期(AECOPD)患者肺功能的影响。方法选取在商丘市第一人民医院呼吸科进行治疗的AECOPD患者50例,按随机数表法分为两组,各25例。对照组实施常规治疗,观察组在对照组基础上采用纤维支气管镜肺泡灌洗,比较两组肺功能指标及血气分析结果。结果治疗后与对照组比较,观察组第1s用力呼吸量(FEV1)、呼气峰流速(PEF)明显升高,差异有统计学意义(P<0.05);观察组PaO_2较对照组明显改善,差异有统计学意义(P<0.05);两组患者PaCO_2水平对比,差异无统计学意义(P>0.05)。结论给予AECOPD患者纤维支气管镜肺泡灌洗可改善患者肺功能及血气指标,值得临床推广。

Objective To investigate the effect of bronchoalveolar lavage on pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）.Methods Fifty patients with AECOPD who were treated by Respiratory Department of Shangqiu First People’s Hospital were divided into two groups according to the random number method. The control group was treated with routine therapy. The bronchoalveolar lavage in the observation group was performed on the basis of the control group. The lung function and blood gas analysis were compared between the two groups. Results Compared with the control group, FEV1 and PEF of the observation group were signifcantly higher than those of the control group （P 〈0.05）. The PaO2 of the observation group was signifcantly improved , The difference was statistically signifcant （P 〈0.05）; PaCO2 levels of two groups of patients, the difference was not statistically signifcant （P〉 0.05）. Conclusion Bronchoalveolar lavage can improve lung function and blood gas index in patients with AECOPD. It is worthy to be popularized.