补肾祛瘀汤治疗多囊卵巢综合征伴胰岛素抵抗的临床研究

Clinical Study on Treatment of Polycystic Ovary Syndrome with Insulin Resistance by Bushen Quyu Decoction

目的研究补肾祛瘀汤联合二甲双胍治疗多囊卵巢综合征的临床疗效。方法选取伴有胰岛素抵抗的多囊卵巢综合征的患者共60例,将其半随机分为研究组和对照组,其中研究组患者采用中药联合二甲双胍治疗,对照组单纯采用二甲双胍治疗。对比两组患者空腹胰岛素的变化(FIN)、空腹血糖(FBS)、胰岛素抵抗指数(HOMA-IR)、体重指数(BMI)、腰臀比(WHR)及血清性激素变化情况。结果两组患者FIN、HOMA-IR、BMI在治疗3个月后均有所下降,且研究组腹胀腹泻等副作用更少,依从性更好,两组比较具有统计学差异下降明显,具有统计学差异(P<0.05);两组患者血浆性激素T、LH、LH/FSH在治疗3个月后均有所下降,且研究组下降明显,具有统计学差异(P<0.05)。结论中药联合二甲双胍治疗多囊卵巢综合征可改善FIN及HOMA-IR,改善卵巢功能,减低BMI及WHR,减轻二甲双胍的副作用,效果满意。

Objective To study the clinical effect of Bushen Quyu Decoction combined with metformin inthe treatment of polycystic ovary syndrome. Methods Sixty patients with polycystic ovary syndrome with insulinresistance were randomly divided into study group and control group. The patients in the study group were treatedwith traditional Chinese medicine combined with metformin and the control group was treated with metforminalone. （FBS）, insulin resistance index （HOMA-IR）, body mass index （BMI）, waist-to-hip ratio （WHR） and serumsex hormones were compared between the two groups. Results The levels of FIN, HOMA-IR and BMI in the twogroups were decreased after 3 months of treatment, and the side effects of abdominal distension and diarrhea wereless and the compliance was better. The difference between the two groups was statistically significant （P〈0.05）. Thelevels of plasma sex hormones T, LH and LH / FSH were decreased in the two groups after 3 months of treatment,and the difference was significant （P〈0.05）. Conclusion Chinese medicine combined with metformin treatmentof polycystic ovary syndrome can improve FIN and HOMA-IR, improve ovarian function, reduce BMI and WHR,reduce the side effects of metformin, the results are satisfactory.