脑微观重建系统研究

Micro reconstruction system for brain

本文旨在研究如何利用硬件,软件,算法的系统工程的方案解决脑微观结构重建的高通量自动化数据分析的难题.通过实现样片制备,自动切片,显微成像,三维重建以及软件平台等分阶段工作,建立符合神经结构生物学特征的模式识别和机器学习分类方法,解决海量畸变图像拼接配准,密集神经结构识别,歧义神经联结,多源数据融合等限制分析效率的关键问题,为搭建大体量神经结构重建工程平台提供理论基础和解决方案,满足脑科学研究对高通量神经回路网络重建的需求.

This paper aims to solve the problem of high throughput automated data analysis of brain microstructure reconstruction by using the solution of systems engineering that consists of hardware, software and algorithm. To solve the key issues of limit analysis efficiency such as registration of large- volume distorted image, dense neural structure recognition, ambiguous neural connections and multi-source data fusion etc, classification method in accordance with the biological characteristics of neural structure is proposed by the realization of the samples preparation, automatic cutting, microscopic imaging, 3D reconstruction and software platform building etc. Furthermore, it provides a theoretical basis and solution for building engineering platform for large volume neural structure reconstruction and meets the brain science research of high-throughput neural circuit network reconstruction demand.