液-质联用技术分析体内药物代谢物的研究进展

Progress of Application of LC-MS/MS Technology in Analysis of in Vivo Drug Metabolites

现代分析技术快速发展,提供了许多检测药物及其代谢产物的方法。液-质联用技术(LC-MS/MS)凭借其简便、快速的特点成为了代谢物分析中最常用的方法之一。笔者将综合近年来应用LC-MS/MS技术对体内药物代谢物研究的报道,就数据采集及处理、代谢物检测及鉴定、应用软件辅助等过程进行归纳整理。为应用LC-MS/MS技术研究药物的体内代谢过程提供依据。

The rapid development of modem analytical technology provides many methods of detecting drugs and their metabolites. LC-MS/MS technology has become one of the most commonly used methods in drug metabolites analysis with its characteristics of sim- pleness and high efficiency. In this paper,based on the published articles of in vivo drug metabolites study by LC-MS/MS in recent years, the processes of data acquisition and processing, metabolites detecting and identification and software-assisting were summarized. This article provides references for research on drug metabolism using LC-MS/MS.