密蒙花化学成分的研究

Chemical Constituents from Buddleja officinalis

目的研究马钱科醉鱼草属植物密蒙花花蕾及花序的化学成分。方法利用硅胶,Sephadex LH-20凝胶等柱色谱分离纯化技术对密蒙花花蕾及花序的化学成分进行分离纯化。结果从该植物花蕾及花序中分离并鉴定了16个化合物,分别为刺槐素(1),芹菜素(2),木犀草素(3),刺槐素-7-O-葡萄糖苷(4),秋英苷(5),木犀草素-7-O-葡萄糖苷(6),刺槐素-7-O-葡萄糖醛酸苷(7),芹菜素-7-O-葡萄糖醛酸苷(8),蒙花苷(9),木犀草素-7-O-芸香糖苷(10),密蒙花新苷(11),毛蕊花糖苷(12),西红花苷Ⅲ(13),西红花苷Ⅱ(14),西红花苷Ⅰ(15),和N^1,N^5,N^(10)-(E)-tri-p-coumaroylspermidine(16)。结论化合物4,7,8,14~16为首次从该药用植物中分离得到,其中7,8,14~16为首次从马钱科中分离得到。

OBJECTIVE To study the chemical constituents from the flower buds and inflorescences of Buddleja officinalis. METHODS Various chromatographic techniques such as silica gel and Sephadex LH -20 chromatography were used in this experi- ment. RESULTS Sixteen compounds were isolated from the medicinal plant, and their structures were identified as follows： acacetin （ 1 ）, apigenin （ 2）, luteolin （ 3 ）, acacetin-7-O-glucoside （ 4 ）, cosmosiin （ 5 ）, luteolin-7-O-glucoside （ 6 ）, acacetin-7-O-glucuronide （ 7 ）, apigenin-7-O-glucuronide （ 8 ）, linarin （ 9 ）, luteolin-7-O-rutinoside （ 10 ）, neobudofficide （ 11 ）, acteoside （ 12）, crocin Ⅲ （ 13 ）, erocin Ⅱ（14）, crocin Ⅰ（15）, and N1, N5, N10-（E）-tri-p-coumaroylspennidine（16）. CONCLUSION Compounds 4, 7, 8, 14 - 16 are obtained from the medicinal plant for the first time, and compounds 7, 8, 14 - 16 are obtained from Loganiaceae for the first time.