滋阴活血方联合氨氯地平对高血压合并冠心病疗效分析

Curative Effect Analysis of Using Amlodipine Combined with Nourishing Yin and Promoting Blood Flow Prescription in Treating Hypertension in Association with Coronary Heart Disease

目的:探讨滋阴活血方、氨氯地平联合治疗高血压合并冠心病的临床疗效。方法:在本院内科就诊的病人中,选取110例高血压合并冠心病患者,分为联合组55例,给予氨氯地平和滋阴活血方联合治疗;剩余55例为对照组,给予氨氯地平加常规治疗。比较两组收缩压(SBP)、舒张压(DBP)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)和中医症候评分、临床疗效。结果:治疗后,联合组SBP(125.5±19.3)mm Hg、DBP(81.5±9.5)mm Hg、TG(1.4±0.4)mmol/L、TC(4.3±0.7)mmol/L;对照组SBP(149.2±18.9)mmHg、DBP(95.3±9.3)mm Hg、TG(3.0±0.4)mmol/L、TC(5.7±0.8)mmol/L,皆明显联合组,差异均有统计学意义(P<0.05)。联合组HDL(1.5±0.3)、LDL(3.7±0.6);对照组HDL(1.0±0.4)、LDL(4.3±0.5),两组比较无明显差异,差异无统计学意义(P>0.05)。联合组中医症候评分总分为(43.9±10.9),明显小于对照组中医症候评分总分(55.8±11.4),差异有统计学意义(P<0.05)。联合组总有效率92.7%;对照组总有效率78.2%,明显小于联合组,差异有统计学意义(P<0.05)。结论:滋阴活血方可辅助氨氯地平的降压效果,对心血管系统起到保护作用,促进血运通畅,从而使动脉血管硬化的情况,得以改善。

Objective： To discuss the clinical efficacy of amlodipine combined with Nourishing-Yin and Promoting-blood Flow Prescription in treating hypertension in association with coronary heart disease. Methods： 110cases of patients with hyper- tension in association with coronary heart disease admitted in medical department of our hospital were selected and divided into two groups. There were 55cases of patients in combination group, for which treatment of amlodipine combined with Nourishing-Yin and Promoting-blood Flow Prescription were provided; and the rest 55cases were set as controlled group and were provided with amlodipine and routine treatment. Two groups were compared for systolic blood pressure （SBP）, diastolic blood pressure （DBP） , triacylglycerol （TC） , high-density lipioprotein （HDL） , low density lipoprotein （LDL） and Chinese medicine symp- tom complex score as well as clinical efficacy. Results： After treatment, in combination group, SBP, DBP, TG and TC were （125.5±19.3） mmHg, （81.5±9.5） mmHg, （1.4±0.4） retool/L, and （4.3±0.7） mmol/L respectively, while thoseof the controlled group were （149.2±18.9） mmHg, （95.3±9.3） mmHg, （3.0±0.4） mmol/L and （5.7±0.8） mmol/L re- spectively, and were obviously higher than those in the combination group, with difference had statistical significance （P〈 0. 05 ）. The HDL and LDL of the combination group were （ 1.5 ±0. 3 ） and （ 3.7 ± 0. 6 ） respectively, while those of the con- trolled group were （1.0±0. 4 ） and （4. 3 ±0. 5 ）, and there were no significant difference between the two groups, with difference had no statistical significance （P〉O. 05 ）. The Chinese medicine symptom complex score of the combination group was （43.9±10. 9 ） which was obviously smaller than that of the controlled group with （55.8± 11.4）, and the difference had statistical signifi- cance （P〈0.05）. The total efficacy of the combination group was 92.7%, and that of the controlled group was 78.2%, which was obviously smaller than the combination group, with difference had statistical significance （ P〈0. 05 ）. Conclusion ： Nouris- hing-Yin and Promoting-blood Flow Prescription can enhance antihypertensive efficacy of amlodipine and protect cardiovascular system. It can facilitate blood circulation and optimize the artery blood vessel sclerosis.