独活寄生汤治疗骨质疏松性椎体压缩骨折患者对VAS及椎体恢复高度影响研究

Effect of Using Duhuo Jisheng Decoction in the Treatment of Osteoporotic Vertebral Compression Fractures in Patients with VAS and the influence Research on Restoration of Vertebral Height

目的:观察独活寄生汤对椎体后凸成形术术后辅助治疗的作用,观察其在缓解患者骨质疏松性椎体压缩骨折疼痛方面的效果,以及其对椎体恢复高度的影响。方法:应用回顾总结分析法,收集2011年1月~2014年1月三年内我院共300例符合要求的骨质疏松性椎体压缩骨折患者,依据患者资料将其分为3组:A组(108例)应用PKP技术后结合独活寄生汤,B组(99例)应用PKP技术,C组(93例)应用独活寄生汤;三组的疗程均为一个月(30天),记录患者治疗前,治疗后一周、一个月、三个月VAS进行评分并行X线检查对椎体高度恢复进行评估,对比患者治疗前后血清骨钙素(BGP)、碱性磷酸酶(ALP)和Ⅰ型前胶原氨基端前肽(PINP)水平的变化情况。结果:通过整理分析相关资料,得出三组患者较治疗前都有明显好转;三组术后治疗一周后A、B组的VAS等级比C组等级低;治疗一月后A组比B组减轻疼痛的作用更好,而C组的治疗效果不如A、B组;治疗三个月后通过比较得出A组是三组中疼痛缓解效果最好的;患者椎体高度的恢复A组效果最好,其椎体高度的恢复以椎体前部和中部明显;A组治疗一周后其血清血清BGP、ALP、PINP水平较治疗前效果显著,且最终效果优于B、C组。结论:独活寄生汤在短时间内缓解疼痛的效果并不理想,但效果维持时间较长;单独行PKP手术可以短时间内缓解患者疼痛,但并不能持久保证效果,有时患者疼痛会加重,因此独活寄生汤作为骨质疏松性椎体压缩骨折VAS和椎体高度恢复的术后辅助治疗方法,在减轻并长期维持患者疼痛方面是很有效果的且被认为是安全、有效的治疗方法。

Objective： To investigate the effect of Duhuo Jisheng Decoction on the role of adjuvant therapy for kyphoplastyafter surgery, observed in patients with osteoporotic vertebral compression fractures pain effect, and the restoration of vertebralheight influence. Methods： Using retrospective analysis method, from January 2011to January 2014in our hospital a total of300patients with osteoporotie vertebral compression fracture patients according to requirements, the patients were divided into3groups： A group （108cases） after the application of PKP technology combined with Duhuo Jisheng Decoction, group B（99eases） by PKP technology, C group （93cases） application of Duhuo Jisheng Decoction; Three groups were treated for onemonth （30days）, were recorded before treatment, after treatment for a week, a month, three months VAS score parallel X-rayexamination in the vertebral height restoration assessment （BGP）, alkaline phosphatase （ALP） and type I procollagen amino ter-minal propeptide （PINP） levels were measured before and after treatment. Results： Through the analysis of relevant informa-tion, the patients in the three groups before treatment were improved obviously; the three groups after a week after treatment, theVAS grade level of the group A and the group B was lower than the group C ; better therapeutic effect of the A group was morethan the B group and the group C to reduce pain, the treatment effect was not as good as the group A and B ; three months aftertreatment compared with the group A in the three group was the best pain relief effect; Patients with restoration of vertebral bodyheight was the best, the restoration of vertebral body height in the front and middle vertebral body was the serum levels of BGP,ALP and PINP in group A were significantly higher than those in group B and group C after one week of treatment. Conclusion ：Duhuo Jisheng Decoction in a short period of time to relieve the pain of the effect is not ideal, but the effect is maintained for along time ; PKP alone in a short time surgery can relieve the pain of patients, but can not guarantee lasting effect, sometimes thepain will increase, therefore Duhuo Jisheng Decoction as adjunct therapy osteoporotic vertebral body height recovery VAS verte-bral fracture and postoperative and long-term maintenance, to reduce the pain of patients is very effective and is considered to bea safe and effective treatment method.