中西医结合治疗慢性胃炎合并幽门螺旋杆菌感染者的疗效观察

Clinical observation on treatment of chronic gastritis with Helicobacter pylori infection by integrated traditional Chinese and western medicine

目的探讨采用中西医结合治疗幽门螺旋杆菌感染引起的慢性胃炎的疗效。方法选取本院2013年8月至2015年12月收治的慢性胃炎患者共240例,按照随机数表法分为对照组和治疗组,每组患者各120例。对照组患者给予阿莫西林联合克拉霉素治疗,治疗组患者于服用阿莫西林联合克拉霉素基础上结合中药调理。治疗周期均为30 d,治疗结束后对比分析两组患者的疗效。结果治疗组患者总有效率为97.5%,显有效率为10%,显著高于对照组的总有效率(93.33%)和显有效率(8.33%),差异均具有统计学意义(χ2=3.317、P=0.012,χ2=2.103、P=0.035)。治疗结束后,治疗组患者胃黏膜萎缩程度与对照组差异无统计学意义,治疗组患者幽门螺旋杆菌的转阴率高于对照组,差异具有统计学意义(χ2=2.235、P=0.034)。结论采用中医和西医相结合的方法治疗幽门螺旋杆菌感染引起的慢性胃炎效果显著。

Objective To investigate the use of traditional Chinese and western medicine treatment of Helicobacter pylori infection caused by chronic gastritis effect. Methods Total of 240 patients with chronic gastritis were collected from August 2013 to December 2015, dividing into control group and treatment group according to the random number table method, 120 cases in each group. The patients in the control group were treated with amoxicillin and clarithromycin as western medicine. The patients in the treatment group were treated with amoxicillin combined with clarithromycin. Treatment cycle were both 30 days, the efficacy of the two groups of patients were compared after the end of treatment. Results The total effective rate was 97.5% and the effective rate was 10% of patients in treatment group, which was significantly higher than that of the control group （93.33%and 8.33%）, with significant differences （χ2 = 3.317, P = 0.012; χ2 = 2.103, P = 0.035）. After treatment, the degree of gastric mucosal atrophy in the treatment group was not significantly different from that in the control group. The negative rate of Helicobacter pylori of patients in the treatment group was higher than that of the control group, with significant difference （χ2 = 2.235, P = 0.034）. Conclusions The combination of traditional Chinese and western medicine in the treatment of Helicobacter pylori infection caused by chronic gastritis effect is significant.