一体化PET/MR分析脑默认网络工作机制

Hybrid PET/MR analysis of neural mechanism for default mode network

目的利用一体化PET/MR探讨脑默认网络功能连接和葡萄糖代谢的空间相关性。方法对9名健康人行一体化PET/MR脑成像,获得同步的静息态MR脑功能成像(fMRI)和PET图像。分析静息态脑默认网络脑区连接与葡萄糖摄取分布的相关性。结果基于静息态fMRI的脑默认网络与PET图像高代谢区域有很好的空间分布相似性。相关性分析显示,右侧后扣带区域内脑功能连接值与相对葡萄糖摄取(rGU)值的相关性最显著(rs=0.833,P<0.001)。结论一体化PET/MR可为研究脑默认网络的神经生理机制提供新的手段。

Objective To investigate the relationship between spatial distribution of default mode network and glucose uptake.Methods Nine healthy subjects were scanned with hybrid PET/MR.Resting state MRI（rs-fMRI）and PET data were obtained.Spatial distribution analysis was performed between default mode network and glucose uptake.The relationship between the functional connectivity of default mode network and the distribution of glucose uptake were further analyzed.Results The similar spatial distribution pattern was found between default mode network and glucose uptake.Correlation between functional connectivity and glucose uptake in the default mode network showed that the best correlation coefficient between the values of functional connectivity and relative glucose uptake（rGU）was achieved in the right posterior cingulate cortex（rs=0.833,P0.001）.Conclusion Hybrid PET/MR is very important to investigate neural mechanism of default mode network.