葛根芩连汤对丙型肝炎肝硬化患者胰岛素抵抗的影响研究

Therapeutic Effectiveness of Gegen Qinlian Decoction on Hepatitis C Cirrhosis With Insulin Resistance

目的探讨葛根芩连汤对丙型肝炎(丙肝)肝硬化患者血清肿瘤坏死因子-α(TNF-α)、白介素-1(IL-1)、白介素-6(IL-6)、超敏C反应蛋白(CRP)、瘦素(LEP)、脂联素(ADP)水平及胰岛素抵抗的影响。方法选取我院收治的丙肝肝硬化患者52例作为研究对象,将其随机均分为两组。对照组采用多烯磷脂酰胆碱胶囊口服治疗;治疗组在对照组基础上,加用葛根芩连汤治疗。治疗前后测定患者的各项指标。结果对照组患者治疗后血清TNF-α、IL-1、IL-6、CRP、LEP、ADP水平和IR指数与治疗前比较,差异无统计学意义(P>0.05);治疗组治疗后血清TNF-α、IL-1、IL-6、CRP、LEP、ADP水平和IR指数较治疗前明显下降,差异均具有统计学意义(P<0.05),且与对照组比较明显下降,差异具有统计学意义(P<0.05)。结论葛根芩连汤可以改善丙肝肝硬化患者胰岛素抵抗状态。

Objective To evaluate the effect of Gegen Qinlian decoction on serum levels of Tumor necrosis factor-α(TNF-α), Interleukin-1(IL-1), interleukin-6(IL-6), high sensitivity c-reactive protein(CRP), leptin(LEP), adiponectin( ADP) level and insulin resistance on 1 iver cirrhosis induced by chronic hepatitis C. Methods 52 cases of hepatitis C cirrhosis according to randomized divided into control group(26 cases) and treatment group(26 cases). Oral treatment administered to the control group(phospholipid choline), treament group in the control group based on Gegen Qinlian decoction treatment, various indicators before and after treatment were detected. Results After treatment, the serum levels of TNF-α, IL-1, IL-6, CRP, LEP, ADP and IR index in the control group were not significantly different from those before treatment(P > 0.05); After treatment, the serum levels of TNF-α, IL-1, IL-6, CRP, LEP, ADP and IR index in the treatment group were significantly decreased compared with those before treatment, the differences were statistically significant(P < 0.05); And compared with the control group decreased significantly, the difference was statistically significant(P < 0.05). Conclusion Gegen Qinlian decoction can improve insulin resistance on the patients of hepatitis C cirrhosis.