晚期前列腺癌间歇与持续性内分泌治疗的临床观察

Clinical Observation of Intermittent and Continuous Endocrine Therapy for Advanced Prostate Cancer

目的探讨晚期前列腺癌间歇与持续性内分泌治疗的临床效果。方法将在我院就诊的晚期前列腺癌患者94例选为研究对象,随机分为两组,47例对照组实施持续性内分泌治疗,47例观察组实施间歇性内分泌治疗,对比两组治疗效果。结果组间在临床疗效及不良反应发生率方面对比,差异有统计学意义(P<0.05);治疗前比较,组间血清PSA水平对比,差异无统计学意义(P>0.05);治疗后两组均有所改善,但组间对比差异无统计学意义(P>0.05)。结论采用间歇性内分泌方式对晚期前列腺癌患者实施治疗效果更理想,且安全性较高。

Objective To investigate the clinical effect of intermittent and continuous endocrine therapy for advanced prostate cancer. Methods 94 cases of patients with advanced prostate cancer were selected as the research object, randomly divided into two groups, 47 cases of control group received continuous endocrine therapy, 47 cases in observation group received intermittent hormonal therapy, compared two groups of treatment efect. Results There were signifcant diferences between the two groups in the clinical efcacy and the incidence of adverse reactions （P 〈 0.05）; Before treatment, there was no signifcant diference in serum PSA levels between groups （P 〉 0.05）; After treatment, the two groups were improved, but there was no signifcant diference between the two groups （P 〉 0.05）. Conclusion The effect of intermittent endocrine therapy on advanced prostate cancer patients is better, and the safety is higher.