术后输注参芪扶正注射液对瓣膜置换患者心肌及免疫功能的影响

The Postoperative Infusion Effect of Shenqi Fuzheng Injection on Immune Function in Patients With Myocardial and Valvular Replacement

目的观察术后输注参芪扶正注射液对瓣膜置换术患者血清心肌功能指标和免疫功能指标的影响并探讨其意义。方法接受心脏瓣膜置换术患者40例,随机分为SF组(术后当天开始在常规治疗基础上加用参芪扶正注射液,250 ml静脉滴注,每日1次,7 d为1个疗程,20例)和Con组(于同期用等量的生理盐水代替,20例),测定两组研究对象术前和术后不同时段患者血清的肌酸激酶(CK)、心肌型肌钙蛋白T(c Tn T)、Ig G、Ig A和Ig M水平,并进行对比分析。结果 SF组在术后24 h、72 h和7 d的血CK和c Tn T明显逐渐降低,Ig G、Ig A和Ig M明显逐渐升高。综合考虑Con组因素,SF组血CK和c Tn T显著逐渐降低,Ig G和Ig A显著逐渐升高,Ig M变化不显著。结论参芪扶正注射液在心脏瓣膜置换术术后对心肌的保护作用显著,并且能提高患者免疫功能,促进患者尽快康复。

Objective To observe the efect of Shenqi Fuzheng Injection on serum myocardial function indexes and immune function indexes in patients undergoing valve replacement and to explore its significance. Methods 40 patients undergoing cardiac valve replacement were randomly divided into group SF （postoperative day on the basis of conventional treatment combined with shenqi fuzheng injection 250 ml intravenous drip, 1 time daily, 7 d for 1 course, 20 cases） and Con group （in the same period with normal saline instead. 20 cases）, determination of serum creatine kinase of patients in different periods of the two groups of subjects before and after surgery （CK）, cardiac troponin T （cTnT）, IgG, IgA and IgM levels, and comparative analysis. Results In the SF group after 24 h, 72 h and 7 d blood CK and cTnT were signifcantly decreased, IgG, IgA and IgM were significantly increased. Considering Con group factors, CK and cTnT in SF group decreased gradually, IgG and IgA increased gradually, and IgM did not change significantly. Conclusion Conclusion Shenqi Fuzheng injection has remarkable protective effect on myocardium after heart valve replacement, and can improve the immune function and promote the rehabilitation of the patients.