基于脾虚生痰理论探讨巨噬细胞自噬与动脉粥样硬化的关系

Exploring the Relationship between Macrophage Autophagy and Atherosclerosis Based on the Theory of Spleen Deficiency Generating Phlegm

从中医病因病机角度而言,细胞自噬机制与中医气的防御功能相一致。脾为后天之本,脾虚则会生痰,在脾失健运、脂质代谢异常状态下,巨噬细胞自噬乏力,胆固醇逆转运受阻,进而影响血管内皮功能,导致动脉粥样硬化性疾病的发生。从中医理论出发,深入探讨巨噬细胞自噬机制,或许会揭示从脾论治动脉粥样硬化相关疾病的微观本质,为临床从脾论治动脉粥样硬化性疾病提供依据。

From the aspect of Chinese medicine etiology and pathogenesis,the mechanism of autophagy is in accord with defending function of Qi in Chinese medicine. Spleen is the foundation of acquired constitution. Spleen deficiency leads to phlegm generating. Under the condition of dysfunction of spleen in transportation and abnormal lipids metabolism,macrophage is weak to autophagy. Reverse cholesterol transport is obstructed. Then vascular endothelial function is affected and atherosclerotic diseases occur. From the aspect of Chinese medicine theory,the authors explore the mechanism of macrophage autophagy in depth,which might reveal the micro-essence of treating atherosclerosis（ AS） related diseases from spleen,to provide reference for clinical treatment.