代谢综合征患者发生胆囊结石危险性研究

Study on Risk of Cholecystolithiasis in Patients with Metabolic Syndrome

目的研究代谢综合征(MS)患者发生胆囊结石的危险性。方法选取我院2006年4月至2010年1月期间的体检者共4 076例,排除过量饮酒、乙肝标志物阳性、严重感染及MS资料不全者,共2 830例纳入研究,其中1 367例在1~3年后再次体检。记录身高、体重、血压、血脂及空腹血糖。结果 BMI≥25 kg/m^2、血压≥140/90 mm Hg、合并MS中2个组分者发生胆囊结石的OR值分别为1.458(95%CI为1.124~1.892,P=0.004)、1.975(95%CI为1.418~2.752,P=0.000)和1.751(95%CI为1.256~2.439,P=0.001)。结论代谢紊乱时发生胆囊结石的风险增加。

Objective To study the risk ofcholecystolithiasis in patients with metabolic syndrome （MS）. Methods 4 076 people with physical examination in our hospital flom April 2006 to January 2010 were selected, and 2 830 people were enrolled excluding those with excessive drinking, positive hepatitis B viruses, severe infection and incomplete MS data. 1 367 cases received physical examination again after 1 to 3 years. The height, weight, blood pressure, blood fat and fasting blood glucose were recorded. Results The OR values of cholecystolithiasis in patients with BMI ≥25 kg/m2, blood pressure ≥ 140/90 mm Hg and two components of MS were respectively 1.458 （95%CI 1.124 - 1.892, P= 0.004）, 1.975 （95%CI 1.418 - 2.752, P= 0.000） and 1.751 （95%CI 1.256 - 2.439, P= 0.001）. Conclusions The risk of cholecystolithiasis increases when metabolism has disorders.