耳后注射联合口服激素治疗平坦下降型突发性聋的临床疗效分析

Clinical curative effect analysis of postauricular topical injection combining with oral hormone in the treatment of the flat type of sudden hearing loss

目的:分析耳后注射联合口服激素治疗平坦下降型突发性聋的临床疗效。方法:收集2015年以来收治的128例平坦下降型突发性聋患者的资料,随机分为耳后注射组(64例,注射用甲泼尼龙琥珀酸钠40mg加利多卡因2.5ml,耳后沟局部注射,隔日1次,联合晨起顿服甲泼尼龙片24mg,连服3d)和非耳后注射组(64例,晨起顿服甲泼尼龙片24mg,连服3d)。采用SPSS 17.0软件对2组患者的听力疗效进行统计分析。结果:(1)耳后注射组中15例(23.4%)治愈,9例(14.1%)显效,24例(37.5%)有效,16例(25.0%)无效,总有效率为75.0%(48/64);非耳后注射组中13例(20.3%)治愈,7例(10.9%)显效,21例(32.8%)有效,23例(35.9%)无效,总有效率为64.1%(41/64);2组患者疗效对比差异有统计学意义(P<0.05);(2)耳后注射组250~8 000 Hz中的低、中、高频等5个不同频率段提高依次为(26.48±6.23)dBHL,(23.24±4.21)dBHL,(21.89±7.34)dBHL,(26.07±7.01)dBHL,(25.75±5.14)dBHL。耳后注射组250~500 Hz及250~4 000 Hz频率段听力改善明显高于非耳后注射组,差异有统计学意义(P<0.05)。结论:耳后注射联合口服激素治疗平坦下降型突发性聋患者疗效较口服激素更佳。

Objective：To analyze the clinical curative effect of postauricular topical injection combining with oral hormone in the treatment of the flat type of sudden hearing loss.Method：Data of 128 patients with the Sudden hearing lossfrom year 2015 till now were collected,and randomly divided into two groups：postauricular topical injection group（methylprednisolone sodium succinatefor injection 40 mg＋linocaine 2.5 ml,retroauricular groove topical injection,qod,combining with taking methylprednisolone tablets 24 mg in the morning for 3 days）and non-postauricular injection group（take methylprednisolone tablets 24 mg in the morning for 3 days）.Use SPSS17.0 software to analyze the hearing curativeeffect of these two groups statistically.Result：（1）The cure rate of postauricular injection group：23.4%（15 cases）,effect appear：14.1%（9 cases）,valid：37.5%（24 cases）,invalid：25.0%（16 cases）,total effective rate：75%（48/64）.The difference compare of these two group has a statistically significant（P0.05）.（2）The cure rate of the flat type patients with the postauricular injection treatment among the total 64 cases is 23.4%,which is higher than the patients without the postauricular injection treatment.The difference compare of these two group has a statistically significant（P0.05）.（3）The incrementsof the postauricular injection group in 250-8 000 Hz,which is divided into7 different frequencies,from low to high,are（26.48±6.23）dBHL,（23.24±4.21）dBHL,（21.89±7.34）dBHL,（26.07±7.01）dBHL,（25.75±5.14）dBHL.The mean value compare of frequency 250-500 Hz and 250-4 000 Hz of these two group has a statistically significant（P0.05）.Conclusion：The curative effect of postauricular topical injection combining with oral hormone in the treatment of the flat type of sudden hearing loss is better than only oral hormone.