补气活血方剂联合弥可保治疗乙胺丁醇中毒性视神经病变的临床研究

Clinical Study on Effect of Buqihuoxue Prescription in Treating Ethambutol-induced Optic Neuropathy with Mecobalamin

目的观察分析补气活血方剂联合弥可保治疗乙胺丁醇中毒性视神经病变的临床效果。方法将2014年6月—2016年6月杭州市红十字会医院眼科门诊确诊乙胺丁醇中毒性视神经病变患者48例随机分为治疗组和对照组,治疗组25例采用补气活血方剂联合化学药弥可保治疗,对照组23例单用化学药弥可保常规治疗,平均随访为3个月,比较评估2组治疗后的临床疗效。结果治疗组的总有效率为96.00%,对照组的总有效率为73.91%,2组治疗后临床疗效比较有显著差异(X^2=4.691,P<0.05)。结论补气活血方剂联合弥可保治疗乙胺丁醇中毒性视神经病变的效果较好,优于常规西药。

OBJECTIVE To observe clinical effect of Buqihuoxue prescription in treating ethambutol-induced optic neuropathy combined with mecobalamin. METHODS Forty-eight ethambutol-induced optic neuropathy patients who were received in outpatient department of ophthalmology in Hangzhou Red Cross Hospital from June 2014 to June 2016 were randomly divided into two groups（treatment group and control group）, 25 patients in treatment group were treated with Buqihuoxue prescription and mecobalamin, 23 patients in control group were treated with mecobalamin. Compared and assessed the clinical curative effect between the two groups after treatment with a mean follow-up of three months. RESULTS Total effective rate in the treatment group and the control group was 96.00% and 73.91%. There were significant differences between the two groups（X2=4.691, P〈0.05）. CONCLUSION The treatment for ethambutol-induced optic neuropathy used by Buqihuoxue prescription with mecobalamin is more satisfied and effective than that with conventional western medicine.