摘要
恶性胶质瘤是最常见和最具破坏性的原发性脑肿瘤,患者的中位总生存率仅15~19月。已有研究证实,胶质瘤干细胞(glioma stem cells,GSCs)是存在于恶性胶质瘤中的一类具有较强自我更新、无限增殖能力和多向分化潜能的与神经干细胞类似的细胞群,并可能在肿瘤抗常规治疗和复发中起到关键性作用。由细胞间质及其中的体液成分构成的GSCs生存微环境,参与调控GSCs的增殖、分化、凋亡、耐药等机制,对维持干细胞的特性及肿瘤的破坏性意义重大。近年来相关微环境研究进展较大,使得胶质瘤的生长、浸润、迁移机制得到了更完善的解释,这也为恶性胶质瘤的治疗提供了新思路。本文将着重从GSCs的血管微环境、缺氧微环境、免疫微环境及其治疗靶点等方面进行综述。
Glioblastoma is the most common and devastating primary brain tumor, with only 15-19 months. It has been confi rmed that glioma stem cells(GSCs) is one type of cancer stem cells in malignant glioma showing the abilities of self-renewal, unlimited proliferation and multi-directional differentiation of neural stem-like cells. GSCs may play a critical role in the resistance to conventional treatment and tumor relapse. The microenvironment, composed of interstitial cells and body fl uid components, regulates the proliferation, differentiation, apoptosis, drug resistance and other mechanisms in GSCs. It does necessarily affect the characteristics of stem cells and tumor malignant phenotype. In recent years, signifi cant progress has been made, opening new avenues in investigating the mechanisms of growth, invasion and migration of glioma and its interaction with microenvironment. This review focuses on the impact of microenvironment including abnormal vasculature, hypoxia and immunosuppression on GSCs, and its potential therapeutic targets for selective inhibition of GSCs.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2017年第11期764-768,共5页
Cancer Research on Prevention and Treatment
基金
国家自然科学基金(81572495
81573239)
武汉市中青年医学骨干人才培养工程
关键词
胶质瘤干细胞
血管微环境
缺氧微环境
免疫微环境
治疗靶点
Glioma stem cells
Vascular microenvironment
Hypoxic microenvironment
Immune microenvironment
Therapeutictargets