氨氯地平联合瑞舒伐他汀钙治疗高血压合并颈动脉粥样硬化的临床疗效

Clinical effect of amlodipine combined with rosuvastatin calcium in treating hypertension with carotid atherosclerosis

目的探讨氨氯地平联合瑞舒伐他汀钙治疗高血压合并颈动脉粥样硬化的临床疗效。方法选取江苏省兴化市人民医院2015—2016年收治的高血压合并颈动脉粥样硬化患者80例,随机分为观察组和对照组,各40例。观察组患者予以瑞舒伐他汀钙片联合苯磺酸氨氯地平片治疗,对照组患者予以苯磺酸氨氯地平片治疗,两组患者均连续治疗30 d。比较两组患者治疗前及治疗3、6个月后血压水平、颈动脉内膜中层厚度(IMT)、颈动脉粥样硬化病变体积(PV)和血清超敏C反应蛋白(hs-CRP)水平,观察两组患者不良反应发生情况。结果治疗前,两组患者收缩压、舒张压、颈动脉IMT与PV、血清hs-CRP水平比较,差异无统计学意义(P>0.05);治疗3、6个月后,观察组患者收缩压、舒张压及血清hs-CRP水平低于对照组,颈动脉IMT与PV小于对照组(P<0.05)。观察组总有效率为95.00%,高于对照组的82.50%(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论氨氯地平联合瑞舒伐他汀钙片治疗高血压合并颈动脉粥样硬化的临床疗效确切,可有效缓解患者临床症状,降低血压水平,且安全性较高。

Objective To investigate the clinical effect of amlodipine combined with rosuvastatin calcium in treating hypertension with carotid atherosclerosis. Methods A total of 80 cases of hypertension with carotid atherosclerosis patients were selected from 2015 to 2016 years in Xinghua City People’s Hospital of Jiangsu Province,which were randomly divided into observation group and control group,40 cases in each group. Patients in observation groups were treated with amlodipine combined with rosuvastatin tablets,and patients in control group were treated with amlodipine tablets,both groups were treated for 30 days. The blood pressure,carotid intima-media thickness（ IMT）,carotid atherosclerotic lesion volume（ PV） and serum high sensitivity C reactive protein（ hs-CRP） before treatment and after treatment of 3,6 months were compared between the two groups,and the incidence of adverse reactions were observed. Results Before treatment,no significat differences of systolic blood pressure,diastolic blood pressure,carotid of IMT,PV or hs-CRP was found between the two groups（ P 〉 0. 05）;after treatment of 3,6 months,the observation group of systolic blood pressure,diastolic blood pressure and hs-CRP were lower than control group,and the carotid of IMT,PV were less than control group（ P 〈 0. 05）. The total efficiency rate of observation group（ 95. 00%） was higher than control group（ 82. 50%）（ P 〈 0. 05）. No significat differences of the incidence rate of adverse reactions was found between the two groups（ P 〉 0. 05）. Conclusion The combination of amlodipine and rosuvastatin have an exactly clinical effect in treating hypertension with carotid atherosclerosis,it can effectively alleviate the clinical symptoms of patients,reduce the blood pressure,and with higher safety.