T淋巴细胞亚群检测在恶性肿瘤患者中的预测价值

Application value of T lymphocyte subsets in malignant tumor patients

目的探讨T淋巴细胞亚群在恶性肿瘤患者中的预测价值。方法选取福建省泉州市第一医院2015年1月—2016年4月收治的恶性肿瘤患者80例作为研究组,另选择本院同期进行健康体检患者80例作为对照组。测定比较两组患者T淋巴细胞亚群(CD_3^+细胞分数、CD_4^+细胞分数、CD_8^+细胞分数),比较研究组不同肿瘤患者T淋巴细胞亚群水平及研究组中死亡患者与未死亡患者入院时T淋巴细胞亚群水平。结果研究组患者CD_3^+细胞分数、CD_4^+细胞分数低于对照组,CD_8^+细胞分数高于对照组(P<0.05)。研究组不同肿瘤患者T淋巴细胞亚群水平比较,差异无统计学意义(P>0.05)。死亡患者CD_3^+细胞分数、CD_4^+细胞分数低于未死亡患者,CD_8^+细胞分数高于未死亡患者(P<0.05)。结论 T淋巴细胞亚群对于判断恶性肿瘤患者免疫水平、分析患者预后具有重要价值。

Objective To investigate the application value of T lymphocyte subsets in malignant tumor patients.Methods A total of 80 cases of malignant tumor patients were selected from January 2015 to April 2016 in Quanzhou First Hospital as study group,and 80 cases of health patients were selected as control group. The T lymphocyte subsets（ CD3＋ cell fraction,CD4＋ cell fraction,CD8＋ cell fraction） were compared between the two groups,and the T lymphocyte subsets of different diseases in study group and the T lymphocyte subsets of death or not patients in study group were compared. Results The study group of CD3＋ cell fraction,CD4＋ cell fraction were lower than control group,CD8＋ cell fraction was higher than control group（ P〈 0. 05）. No significant differences of T lymphocyte subsets was found among the different diseases in study group（ P 〉 0. 05）.The death patients of CD3＋ cell fraction,CD4＋ cell fraction were lower than none-death group,CD8＋ cell fraction was higher than none-death group（ P 〈 0. 05）. Conclusion T lymphocyte subsets analysis has an important value in determining the immune levels and prognosis of patients.