Study on the interaction between polymorphisms of FOXO3A gene and environmental factors in longevity at Bama county,Guangxi province

Objective: To study the interaction between the polymorphisms of FOXO3A and the environmental factors in the longevity district of Bama county.Methods: Using Taqmaq probe,genotyping of FOXO3A gene was performed for 200 longevous elderly(aged 90-110)and 288 healthy controls(aged 48-89).The interaction between the polymorphisms of gene and environmental factors were analyzed by using conditional logistic regression.Results: Minor allele frequencies(MAF)of five known SNPs in FOXO3A gene were higher in cases than in controls(P<0.05).There was a positive interction between minority alleles of rs2764264 in FOXO3A gene and the environment factors in the longevity district(OR=11.08,γ=1.075).Conclusion: Five SNPs of FOXO3A gene would be closely correlated with human longevity in Bama.The interaction between the polymorphisms of FOXO3A genes rs2764264 and the environment factors in the longevity district had synergy to longevity.The longevity phenomenon in Bama probably was the result of the interaction between gene and environmental factors.

Objective： To study the interaction between the poly- morphisms of FOXO3A and the environmental factors in the longevity district of Bama county. Methods： Using Taqmaq probe, genotyping of FOXO3A gene was performed for 200 longevous elderly （aged 90-110） and 288 healthy controls （aged 48-89）. The interaction between the polymorphisms of gene and environmental factors were analyzed by using conditional logistic regression. Results： Minor allele frequencies （MAF） of five known SNPs in FOXO3A gene were higher in cases than in controis （P〈0. 05）. There was a positive intercfion between minority alleles of rs2764264 in FOXO3A gene and the environment factors in the longevity district（ OR=11.08, y=1. 075）. Conclusion： Five SNPs of FOXO3A gene would be closely correlated with human longevity in Bama. The interaction between the polymorphisms of FOXO3A genes rs2764264 and the environment factors in the longevity district had synergy to longevity. The longevity phenomenon in Bama probably was the result of the interaction between gene and environmental factors.