2型糖尿病患者血清成纤维细胞生长因子-21与下肢动脉粥样硬化的相关性分析

Correlation between serum fibroblast growth factor-21 and low extremity atherosclerosis in T2DM patients

目的分析2型糖尿病患者血清成纤维细胞生长因子-21(FGF-21)与臀围、血脂、血糖及下肢动脉粥样硬化(lower extremity atherosclerosis,LEAD)的相关性。方法测定80例2型糖尿病患者FGF-21水平,分析FGF-21水平与臀围(HC)、肋骨下缘与髂嵴连线中点水平周径(WC)、血脂及血糖的相关性;彩色多普勒超声仪评估患者的下肢动脉,分析血清FGF-21水平与LEAD相关性。结果 LEAD血清FGF-21水平低于非下肢动脉粥样硬化病变(Non-LEAD组),差异有统计学意义(P<0.05)。FGF-21是LEAD的影响因素。校正性别、BMI、年龄三种影响因素后,血清FGF-21水平和WC呈正相关(r=0.255,P<0.05)。WC是血清FGF-21水平的独立影响因素。结论血清FGF-21与2型糖尿病肥胖有关,参与LEAD发展。

Objective To analyze the association of fibroblast growth factor-21 （ FGF-21 ） with hip circumference （ HC）, blood lipid, blood glucose and lower extremity atherosclerosis （LEAD） in patients with type 2 diabetes mellitus （T2DM）. Methods We determined FGF-21 in 80 patients with T2DM and analyzed the association of serum FGF-21 levels with HC,waist circumference （WC）, blood lipid and glucose. The color Doppler ultrasound was used to evaluate the lower extremity artery in these patients： The correlation between serum FGF-21 level and LEAD was analyzed. Results The serum FGF-21 levels in patients with LEAD were lower than that in patients without LEAD （ P 〈 0. 05 ）. FGF-21 was a risk factor of LEDA. After correction of three factors of age, gender and BMI, serum FGF-21 level was positively correlated with WC （r = 0. 255 ,P 〈 0.05） and WC is an independent influencing factor of the serum FGF-21 level. Conclusion Serum FGF-21 is associated with obesity and involved in the development of LEAD.