我院特殊门诊抗抑郁药物的利用分析

Utilization analysis of antidepressant drugs in special outpatient clinic of our hospital

目的了解近年来我院特殊门诊抗抑郁药物的利用趋势,为临床合理用药提供参考。方法由医院信息系统提取2013~2015年我院特殊门诊抗抑郁药使用数据,内容包括品种类别、药品名称、剂型、规格、数量及金额等;采用世界卫生组织推荐的限定日剂量(DDD)、用药数量、金额及用药频度(DDDs)等指标,对相关数据进行统计分析。结果我院特殊门诊使用的抗抑郁药主要有选择性5-羟色胺(5-HT)再摄取抑制剂(SSRIs)、选择性5-HT及去甲肾上腺素(NA)再摄取抑制剂(SNRIs)、NA及特异性5-HT抑制剂(Na SSA)等。2013~2015年特殊门诊抗抑郁药物的使用数量、用药频度及金额均呈逐年上升趋势,其中SSRIs中的艾司西酞普兰、舍曲林和SNRIs中文拉法辛分别占据DDDs和使用金额的前3位。结论我院抗抑郁药使用基本合理,用量较大的SSRIs及SNRIs均是目前抗抑郁药物的一线用药。

Objective To investigate the recent utilization trend of antidepressants in special outpatient clinic in our hospital in order to provide references for rational drug use clinics. Methods Antidepressants medication data of special outpatient clinic in our hospital from 2013 to 2015 were collected from hospital information system including medicine category, medicine name, dosage form, specification, quantity and price. The relevant data were statistically analyzed by means of the index recommended by WHO such as defined daily dose （DDD） ,number of drug,consumption sum and frequency of drug use （DDDs）. Results The main antidepressant categories used in special outpatient clinic in our hospital were selective 5-serutonin （5-HT） reuptake inhibitors （SSRIs）, selective 5-HT and norepinephrine （NA） reuptake inhibitors （ SNRIs）, and NA and specific 5-HT inhibitors （NaSSA）. The quantity, frequency and amount of antidepressants used in special outpatients in our hospital from 2013 to 2015 showed a rising trend year by year,in which the top 3 of DDDs and amount were escitalopram （ SSRIs）, sertraline （SSRIs） and venlafaxine （SNRIs）. Conclusion The usage of antidepressants in our hospital was generally rational. Both selective SSRIs and SNRIs are current antidepressant drugs of first-line treatment.