谷氨酰胺肠内营养在急性胰腺炎治疗中的疗效分析

Curative effect of glutamine enteral nutrition in the treatment of acute pancreatitis

目的探讨谷氨酰胺肠内营养在急性胰腺炎治疗中的疗效。方法 2015年6月至2016年6月入院的80例急性胰腺炎患者,按随机数字表法分为两组,对照组24例给予常规肠内营养,试验组26例加用谷氨酰胺,比较两组患者治疗前后相关临床指标、治疗效果、相关临床事件、住院周期与费用。结果实验组干预后白蛋白(Alb)、前白蛋白(PA)与转铁蛋白(TRF)水平显著高于对照组,谷丙转氨酶(ALT)、谷草转氨酶(AST)、高敏C反应蛋白(hs CRP)、肿瘤坏死因子α(TNF-α)、白介素1β(IL-1β)、白介素6(IL-6)与白介素8(IL-8)水平显著低于对照组;APACHEⅡ评分、CT评分、住院周期、费用、感染率及并发症发生率明显低于对照组(P<0.05)。结论谷氨酰胺肠内营养在急性胰腺炎治疗中的疗效显著,可缩短治疗时间,节省医疗费用。

Objective To investigate the curative effect of glutamine enteral nutrition in the treatment of acute pancreatitis. Methods Eighty patients with acute pancreatitis admitted from June 2015 to June 2016 in our hospital were randomly divided into experimental and control groups. The control group was given normal enteral nutrition while the experimental group was treated with glutamine. Related clinical indicators, curative effect, related clinical events and hospital cycle and cost were compared between the two groups. Results The levels of ALT, AST, hsCRP, TNF-α, IL-1β, IL-6 and IL-8 in the experimental group were significantly higher than those in the control group （P 〈0. 01 ）. In the experimental group,the APACHE II score was significantly lower than that in the control group （P 〈0. 01 ）. The infection rate and complication rate in the experimental group were significandy lower than those in the control group （P 〈0. 05）. Conclusion Glutamine enteral nutrition in the treatment of acute pancreatitis has a significant effect that can shorten the treatment time and save medical costs.