急性冠脉综合征患者新喋呤、D-二聚体和超敏C反应蛋白水平变化

Levels of Neopterin,D-Dimer and High-Sensitivity C-Reactive Protein in Serum of Patients with Acute Coronary Syndrome

目的:观察急性冠脉综合征(ACS)患者新蝶呤(NP)、D-二聚体(DD)和超敏C反应蛋白(hs-CRP)水平变化,探讨其在ACS中的临床应用价值。方法:2016-01-2016-07武汉大学人民医院心内科住院ACS患者120例(观察组),包含不稳定性心绞痛(UA组,n=55)和急性心肌梗死(AMI组,n=65);选择同期健康人群120例为对照(对照组)。采集受试者空腹肘静脉血,采用酶联免疫吸附法测定血清NP,全自动凝血分析仪测定血浆DD,全自动生化分析仪测定血清hs-CRP水平,比较各组各指标差异。结果:观察组NP、DD和hs-CRP浓度较对照组显著升高,分别为NP(2.84±0.05ng/ml vs 1.26±0.07ng/ml),DD(0.51±0.04mg/L vs 0.22±0.06mg/L),hs-CRP(0.52±0.57mg/L vs 0.11±0.52mg/L),差异均有统计学意义(P<0.01);并且AMI组NP、DD和hs-CRP水平高于UA组患者,分别为NP(2.89±0.05ng/ml vs 2.76±0.05ng/ml),DD(0.55±0.04mg/L vs 0.43±0.06mg/L),hs-CRP(0.59±0.63mg/L vs 0.37±0.19mg/L),差异亦有统计学意义(P<0.05)。结论:ACS患者NP、DD和hsCRP指标检测能够有效评估患者病情,具有重要的临床应用价值。

Objective： To investigate the value of clinical application in acute coronary syndrome（ACS） by measuring serum levels of neopterin （NP）, D-Dimer（DD） and high-sensitivity C-reaetive protein（hs-CRP）. Method： We enrolled 120 ACS patients admitted to the Department of Cardiology at Renmin Hospital, Wuhan University be- tween January 2016 and July 2016 into the experimental group（UA group, n= 55, AMI group, n= 65）. At the same time, this study enrolled 120 healthy people into the control group. The subjects were collected from venous venous blood. The enzyme-linked immunosorbent assays（ELISAs）were used to measure the sernm NP level. The DD was assessen using automatic coagulation analyzerand. The hs-CRP was assessed using fully automatic biochemical analyzers. We compared the differences in each group＇s indexes. Results.. The levels of NP, DD and hs-CRP were higher in the experimental group than that in the control group. NP （2.84±0.05） vs （1.26±0.07） ng/ml, DD （0. 51±0.04） vs （0.22±0.06）mg/L, hs-CRP （0.52±0.57） vs （0. 11±0.52）mg/L. In addition, the level of NP, DD and hs-CRP in the AMI group were also higher than that in UA group （P〈0.05）. Concision： The levels of NP, DD and hs-CRP could preferably reflect the severe degree of ACS, and had very important elinieal value.