糖基化改性甜菊苷、橙皮苷及芦丁苷作为新型药物载体的研究与应用

Research Advances in Application of Transglycosylated Stevioside,Hesperidin and Rutin as New Drug Carrier Materials

新型药物载体的开发对药物制剂的研究起到重要作用,随着纳米技术的发展以及药物载体研究的深入,基于糖基化改性的食品添加剂作为药物载体的研究受到了广泛关注。近年来用作药物载体的糖基化改性食品添加剂主要包括糖基化改性甜菊苷(St-G),糖基化改性橙皮苷(Hsp-G)及糖基化改性芦丁苷(Rut-G)。甜菊苷、橙皮苷、芦丁自身具有良好的生物活性与保健功能,作为食品添加剂被广泛应用于食品工业中,但存在味质差或者溶解度低等缺点,通过糖基化改性能够增加甜菊苷、橙皮苷、芦丁结构和功能的多样性,使其在水中能够自组装形成不同聚集数的核-壳纳米结构。因此将糖基化改性食品添加剂作为药物载体具有独特的优点,可使难溶性药物有效增溶,提高生物利用度,同时具有良好的安全性。本文综述了这3种糖基化改性食品添加剂的特点和生物安全性、生物合成方法及其作为药物载体的应用情况,为其在医药领域的应用研究提供新方法和新思路。

The development of new drug carriers plays an important role in the research of pharmaceutical preparations, with the rapid development of nanotechnology and in-depth understanding of drug carrier. The glycosylation of food additives as a drug carrier research has received extensive attention. In recent years, glycosylated stevioside, glycosylated hesperidin and glycosylated rutin have become research focus. Stevioside, hesperidin and rutin as food additive are widely used in the food industry, they have good biological activity and health function with poor taste and low solubility. Glycosylation modification can increase diversity of their structure and function, so that they can self-assemble in water to form core-shell nano-structure with different aggregation number. Transglycosylated food additives as new drug carriers can increase the solubility of the drug and enhance the bioavailability with good safety. In this paper, the properties and biological safety, biosynthesis method and transglycosylated food additives as well as their application in new drug carrier materials were reviewed so as to provide new method and new thinking for its application in the field of medicine.