血液病患者血小板输注治疗的效果及影响因素logistic回归分析

The Effects of Platelet Transfusion in Patients with Hematologic Diseases and Logistic Regression Analysis of the Influencing Factors

目的研究血液病患者血小板输注治疗的效果并对影响因素进行logistic回归性分析。方法回顾性分析我院2013年11月至2015年11月63例血液病患者的临床资料,两组患者均予以血小板输注治疗,比较患者血小板输注前后血小板计数变化以及不同类型血液病患者血小板输注有效率,分析影响血小板输注的相关因素并进行Logistic单因素回归分析。结果输注后血小板计数较输注前显著较高(P<0.05);急性白血病患者、再生障碍性贫血患者血小板输注有效率分别为87.13%、83.02%较特发性血小板减少性紫癜、骨髓异常增生综合征51.28%、67.86%显著较高(P<0.05);反复输血次数≥3次、发生感染、脾肿大、活动性出血患者血小板输注无效率分别为68%、36%、70%、12%较血小板输注有效率30.41%、19.88%、36.26%、4.68%显著较高(P<0.05)。结论反复输注血小板、感染、脾肿大、活动性出血是血小板输注无效的影响因素。

Objective To study the effects of platelet transfusion in：patients with hematologic diseases and Logistic regression analysis of the influencing factors. Methods From November 2013 to November 2015 ,the clinical data of 63 patients with hematologic diseases in our hospital were retrospectively analyzed. All patients were treated with platelet transfusion. The changes of platelet count before and after platelet transfusion and the efficacy of platelet transfusion in patients with different types of hematologic diseases were compared, and the related factors influencing the effects of platelet transfusion were analyzed by univariate Logistic regression analysis. Results After transfusion, the platelet count was significantly higher than that before transfusion （ P 〈 0. 05 ）. The effective rates of platelet transfusion in patients with acute leukemia and aplastic anemia （87. 13%, 83.02% ）were significantly higher than those in patients with idiopathic thrombocytopenic purpura and myelodysplastic syndrome （ 51, 28% , 67.86% ） （ P 〈 0. 05 ）. The ineffective rates of platelet transfusion in patients with ≥ 3 times of repeated transfusion, infection, splenomegaly and active bleeding（68% , 36% , 70% , 12% ） were significantly higher than effective rates （30.41% , 19.88% , 36.26% ,4.68% ） （P 〈 0. 05）. Conclusion Repeated platelet transfusion,infection, splenomegaly and active bleeding are the influencing factors of the effects of platelet transfusion.