高三尖杉酯碱联合地西他滨治疗老年白血病继发血小板增多症

Combination Therapy with Vinorelbine and Capecitabine in Elderly Patients with Leukemia Secondaryto Thrombocytosis

目的观察高三尖杉酯碱、地西他滨联合治疗对老年白血病继发血小板增多症的疗效。方法选取2013年1月~2016年1月确诊为老年白血病继发血小板增多症的124例患者,按照疗法分为联合组(基础化疗+高三尖杉酯碱+地西他滨)和对照组(基础化疗+高三尖杉酯碱)各62例。结果治疗后,联合组Hb、PLT、WBC恢复效果优于对照组,临床总缓解率72.59%高于对照组53.23%(P<0.05)。组间胃肠道反应、脱发、骨髓抑制、肝肾功能损伤等不良反应差异无统计学意义(P>0.05)。结论高三尖杉酯碱联合地西他滨能够促进老年白血病继发血小板增多症患者的血象和骨髓象指标好转,对预后具有改善作用。

Objective To observe the effect of combined treatment with Vinorelbine and Capecitabine on senile leukemia secondary to thrombocytosis. Methods 124 cases from January 2013 January-2016 diagnosed leukemia in the elderly patients with secondary thrombocytosis patients, according to randomly divided into the treatment group （basic therapy chemotherapy ＋ Vinorelbine and Capecitabine ） and control group（chemotherapy ＋ Vinorelbine and）62 cases,. Results After treatment, treatment group Hb, PLT, WBC recovered better than the control group, the total clinical response rate 72.59% higher than control group 53.23% （P 〈 0. 05 ）. No statistical significance adverse reactions between gastrointestinal reactions, hair loss, bone marrow suppression,liver and kidney function injury group （ P 〉 0. 05 ）. Conclusion The combination of Vinorelbine and Capecitabinecan promote the improvement of hemogram and bone marrow index in elderly patients with secondary thrombocytosis, and can improve the prognosis.