家庭随访对低抗凝血酶水平的持续非卧床腹膜透析患者心血管事件发生风险的影响

The Effects of Family Follow-up on Risk of Cardiovascular Events in Continuous Ambulatory Peritoneal Dialysis Patients with low Antithrombin Levels

目的分析探讨家庭随访对低抗凝血酶(AT)水平的持续非卧床腹膜透析(CAPD)患者心血管事件发生风险的影响。方法选取确治疗的接受CAPD治疗的慢性肾衰竭患者共185例进行研究,随机分为两组,其中家庭随访组患者90例,另外95例患者为对照组;研究比较两组患者相关信息,随访比计较2年后心血管事件发生情况;采用SPSS 17.0软件分析数据。结果本研究中家庭随访组中AT≤230 mg/L者与AT>230 mg/L者比较仅见尿量≤500 ml者的比例AT≤230 mg/L者更高(P<0.05);对照组中也仅发现AT≤230 mg/L者尿量≤500 ml的比例更高(P<0.05),符合病理特征。随访比较受试对象心血管事件发生情况:干预后AT≤230 mg/L的受试对象中心血管事件发生率为22.58%,心血管事件死亡率为3.23%,无心血管事件时间平均为(425.36±39.87)d,心血管事件死亡率为3.23%;与同组AT>230 mg/L者比较可见心血管事件发生率更高,无心血管事件时间更短(P<0.05)。而与常规对照组AT≤230mg/L者相比,心血管事件发生率均较低,无心血管事件时间均较长(P<0.05);常规对照组内AT≤230 mg/L的受试对象与AT>230 mg/L者相比较可见心血管事件发生率更高,无心血管事件时间更短(P<0.05)。结论提示低AT表达者心血管事件预后情况普遍更为严重,而家庭随访干预对于全部患者均有一定的控制减低心血管事件发生风险的作用。

Objective To investigate the effect of family follow-up on the risk of cardiovascular events in continuous ambulatory peritoneal dialysis （CAPD）patients with low antithrombin （AT）levels. Methods A total of 185 patients with chronic renal failure who underwent CAPD treatment were randomly divided into two groups：90 patients in the follow-up group and 95 patients in the control group. The patients were followed up for the two groups. Compared with 2 years after the occurrence of cardiovascular events. Results In the study group,ATe〈230 mg/L and AT 〉230 mg/L in the family follow-up group were only higher than those with AT≤230 mg / L,and the control group ≤ 230 mg / L urine output ≤ 500 ml higher proportion,P 〈0.05, consistent with pathological features. The incidence of cardiovascular events was 22.58%, the death rate of cardiovascular events was 3.23% ,and the mean time of cardiovascular events was no more than that in the control group （ P 〈 0. 05 ）. The follow- （425.36 ± 39.87 ） days, the mortality rate of cardiovascular events was 3.23%. Compared with the same group of AT 〉 230 mg / L, the incidence of cardiovascular events was higher,the time of no cardiovascular events was Shorter, P 〈 0. 05. Compared with the conventional control group AT ≤ 230 mg / L, the incidence of cardiovascular events were lower, no cardiovascular events were longer,P 〈 0. 05 ; conventional control group AT ≤230 mg / L of the subjects and AT 〉 230 mg / L compared to the higher incidence of cardiovascular events, no cardiovascular events shorter time,P 〈 0. 05. But there was no statistically significant difference in the mortality rate of cardiovascular events among groups of people.Conclusion The results suggest that the prognosis of cardiovascular events is generally more severe in patients with low AT expression, and family follow-up intervention has a certain effect on all patients to reduce the risk of cardiovascular events.